glyoxylate + alanine => glycine + pyruvate [peroxisome]

Stable Identifier
R-HSA-389684
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Alanine-glyoxylate transaminase (AGXT) catalyzes the irreversible reaction of glyoxylate and alanine to form glycine and pyruvate (Danpure and Jennings 1988). The active form of the enzyme is a homodimer (Zhang et al. 2003) with one molecule of pyridoxal phosphate bound to each subunit (Coulter-Mackie et al. 2005). Mutations in this enzyme are associated with primary hyperoxaluria type I. Mutant alleles encode both catalytically inactive proteins and active ones that are mis-localized to mitochondria (Purdue et al. 1990; Takada et al. 1990).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
alanine-glyoxylate transaminase activity of AGXT dimer [peroxisomal matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created