Reactome | CSF1 dimer binds CSF1R or IL34

Schema > Reaction > Entries

CSF1 dimer binds CSF1R or IL34 Show undefined attributes

authored	[InstanceEdit:389155] Garapati, P V, 2008-12-22 11:20:58 [InstanceEdit:9680351] May, Bruce, 2020-03-14
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:389155] Garapati, P V, 2008-12-22 11:20:58
dbId	389156
displayName	CSF1 dimer binds CSF1R or IL34
edited	[InstanceEdit:389155] Garapati, P V, 2008-12-22 11:20:58 [InstanceEdit:9680351] May, Bruce, 2020-03-14
eventOf	[Pathway:R-HSA-9680350] Signaling by CSF1 (M-CSF) in myeloid cells - Homo sapiens
followingEvent	[Reaction:R-HSA-9680349] CSF1R dimerizes - Homo sapiens
inferredFrom	[Reaction:R-MMU-9680703] Csf1 dimer binds Csf1r - Mus musculus
input	[DefinedSet:R-HSA-9733334] CSF1 dimer, IL34 dimer [extracellular region] [EntityWithAccessionedSequence:R-HSA-197667] CSF1R [plasma membrane]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:389136] Identification of the ligand-binding regions in the macrophage colony-stimulating factor receptor extracellular domain [LiteratureReference:9681134] IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation [LiteratureReference:8854718] Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R [LiteratureReference:9681109] Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1 [LiteratureReference:448611] Discovery of a cytokine and its receptor by functional screening of the extracellular proteome [LiteratureReference:9682755] CSF-1 receptor signaling in myeloid cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CSF1 dimer binds CSF1R or IL34
output	[Complex:R-HSA-9680352] CSF1 dimer,IL34 dimer:CSF1R [plasma membrane]
releaseDate	2022-12-07
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9817996] Stanley, E Richard, 2022-10-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-389156
summation	[Summation:389138] Colony-stimulating factor 1 receptor (CSF1R, CSF-1R) is a pr...

Referrals

(precedingEvent)	[Reaction:R-HSA-9680349] CSF1R dimerizes
(hasEvent)	[Pathway:R-HSA-9680350] Signaling by CSF1 (M-CSF) in myeloid cells
(inferredTo)	[Reaction:R-MMU-9680703] Csf1 dimer binds Csf1r