Reactome | Activated CEBPB and NFKB complex bind IL8 promoter

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Activated CEBPB and NFKB complex bind IL8 promoter Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3857307] Orlic-Milacic, M, 2013-07-09
dbId	3857308
displayName	Activated CEBPB and NFKB complex bind IL8 promoter
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
eventOf	[Pathway:R-HSA-2559582] Senescence-Associated Secretory Phenotype (SASP) - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-3790137] Stimulation of IL8 transcription in senescent cells - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3788737] IL8 gene [nucleoplasm] [Complex:R-HSA-194047] NFKB1(1-433):RELA [nucleoplasm] [Complex:R-HSA-3857334] p-T235,S321-CEBPB homodimer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3857340] Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network [LiteratureReference:4608687] Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8 [LiteratureReference:4608694] NF-kappa B subunit-specific regulation of the interleukin-8 promoter [LiteratureReference:4608696] Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-kappa B [LiteratureReference:4613336] Interleukin-1 alpha activates an NF-kappaB-like factor in osteoclast-like cells [LiteratureReference:4613325] Interleukin 1alpha-induced NFkappaB activation and chemokine mRNA stabilization diverge at IRAK1 [LiteratureReference:4613327] Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated CEBPB and NFKB complex bind IL8 promoter
output	[Complex:R-HSA-3857319] p-T235,S321-CEBPB:NF-kB:IL8 Gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-3857336] CEBPB homodimerization - Homo sapiens
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
revised	[InstanceEdit:4648961] Orlic-Milacic, M, 2013-09-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3857308
summation	[Summation:3858379] RAS-mediated activation of CEBPB (C/EBP-beta) stimulates CEB...
updateTrackers	[UpdateTracker:9781734] Update Tracker - [Reaction:3857308] Activated CEBPB and NFKB complex bind IL8 promoter - v60:[add_removeInput] [UpdateTracker:9786951] Update Tracker - [Reaction:3857308] Activated CEBPB and NFKB complex bind IL8 promoter - v47:[addInput, addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9781734] Update Tracker - [Reaction:3857308] Activated CEBPB and NFKB complex bind IL8 promoter - v60:[add_removeInput] [UpdateTracker:9786951] Update Tracker - [Reaction:3857308] Activated CEBPB and NFKB complex bind IL8 promoter - v47:[addInput, addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-2559582] Senescence-Associated Secretory Phenotype (SASP)
(precedingEvent)	[BlackBoxEvent:R-HSA-3790137] Stimulation of IL8 transcription in senescent cells