Activated CEBPB and NFKB complex bind IL8 promoter

Stable Identifier
R-HSA-3857308
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Activated CEBPB and NFKB complex bind IL8 promoter
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RAS-mediated activation of CEBPB (C/EBP-beta) stimulates CEBPB binding to the IL8 promoter (Kuilman et al. 2008). NFKB transcription complex, activated by interleukin-1-alpha (IL1A) signaling (Jimi et al. 1996, Hartupee et al. 2008, Orjalo et al. 2009), also binds the promoter of the IL8 gene (Kunsch and Rosen 1993) and cooperates with CEBPB in the activation of IL8 transcription (Matsusaka et al. 1993, Stein and Baldwin 1993).
Literature References
PubMed ID Title Journal Year
8617720 Interleukin-1 alpha activates an NF-kappaB-like factor in osteoclast-like cells

Jimi, E, Ikebe, T, Takahashi, N, Hirata, M, Suda, T, Koga, T

J. Biol. Chem. 1996
8413306 Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-kappa B

Stein, B, Baldwin, AS

Mol. Cell. Biol. 1993
18411265 Interleukin 1alpha-induced NFkappaB activation and chemokine mRNA stabilization diverge at IRAK1

Hartupee, J, Li, X, Hamilton, T

J. Biol. Chem. 2008
19805069 Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

Orjalo, AV, Bhaumik, D, Gengler, BK, Scott, GK, Campisi, J

Proc. Natl. Acad. Sci. U.S.A. 2009
8234276 Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8

Matsusaka, T, Fujikawa, K, Nishio, Y, Mukaida, N, Matsushima, K, Kishimoto, T, Akira, S

Proc. Natl. Acad. Sci. U.S.A. 1993
18555778 Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

Kuilman, T, Michaloglou, C, Vredeveld, LC, Douma, S, van Doorn, R, Desmet, CJ, Aarden, LA, Mooi, WJ, Peeper, DS

Cell 2008
8413215 NF-kappa B subunit-specific regulation of the interleukin-8 promoter

Kunsch, C, Rosen, CA

Mol. Cell. Biol. 1993
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Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-07-09)
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