Reactome | GLP1R:GLP1 activates G(s)

Schema > Reaction > Entries

GLP1R:GLP1 activates G(s) Show undefined attributes

authored	[InstanceEdit:422324] May, B, 2009-05-28 03:42:50
catalystActivity	[CatalystActivity:9857000] G protein-coupled receptor activity of GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:381677] May, B, 2008-11-19 21:15:12
dbId	381706
displayName	GLP1R:GLP1 activates G(s)
edited	[InstanceEdit:422324] May, B, 2009-05-28 03:42:50
eventOf	[Pathway:R-HSA-381676] Glucagon-like Peptide-1 (GLP1) regulates insulin secretion - Homo sapiens
followingEvent	[Reaction:R-HSA-422320] Heterotrimeric G(s) complex dissociates - Homo sapiens
inferredFrom	[Reaction:R-RNO-446954] Activation of G(s) by the Glucagon-like peptide-1 receptor (Glp1r, rat) - Rattus norvegicus
input	[Complex:R-HSA-422310] GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:381700] Mechanisms of action of glucagon-like peptide 1 in the pancreas [LiteratureReference:381683] Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor [LiteratureReference:381633] G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes [LiteratureReference:381641] Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential [LiteratureReference:446662] Functional Characterization of N-Terminally GFP-Tagged GLP-1 Receptor
modified	[InstanceEdit:9860913] D'Eustachio, Peter, 2024-02-12
name	GLP1R:GLP1 activates G(s)
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-422311] GLP-1:GLP-1R:Heterotrimeric G(s):GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-381612] GLP1R binds GLP1 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2009-06-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422557] Gillespie, ME, 2009-06-02 00:59:01 [InstanceEdit:913479] Calamita, G, 2010-07-15 [InstanceEdit:9860914] Hill, David P, 2024-02-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-381706
summation	[Summation:381600] GLP-1R that has bound GLP-1 activates the alpha subunit of t...

Referrals

(hasEvent)	[Pathway:R-HSA-381676] Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
(precedingEvent)	[Reaction:R-HSA-422320] Heterotrimeric G(s) complex dissociates
(inferredTo)	[Reaction:R-RNO-446954] Activation of G(s) by the Glucagon-like peptide-1 receptor (Glp1r, rat)