Reactome | DSB inducing agents induce double strand DNA breaks

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DSB inducing agents induce double strand DNA breaks Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3785710] Orlic-Milacic, M, 2013-07-03
dbId	3785704
displayName	DSB inducing agents induce double strand DNA breaks
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15 [InstanceEdit:5692523] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-2559586] DNA Damage/Telomere Stress Induced Senescence - Homo sapiens [Pathway:R-HSA-5693548] Sensing of DNA Double Strand Breaks - Homo sapiens
followingEvent	[Reaction:R-HSA-3785768] MRN complex binds DNA double strand breaks - Homo sapiens
input	[DefinedSet:R-ALL-6783909] DSB inducing agents [nucleoplasm] [GenomeEncodedEntity:R-HSA-5649637] dsDNA [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3785703] Reactive oxygen species-induced DNA damage and its modification: a chemical investigation [LiteratureReference:6783908] DNA repair dysregulation from cancer driver to therapeutic target
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DSB inducing agents induce double strand DNA breaks
output	[OtherEntity:R-ALL-75165] DNA double-strand break ends [nucleoplasm]
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03 [InstanceEdit:5693179] Borowiec, James A, 2015-06-12
revised	[InstanceEdit:6783898] Orlic-Milacic, Marija, 2015-06-17
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-3785704
summation	[Summation:3785709] Reactive oxygen species (ROS) induce DNA double-strand break...
updateTrackers	[UpdateTracker:9776079] Update Tracker - [BlackBoxEvent:3785704] DSB inducing agents induce double strand DNA breaks - v78:[modifyText] [UpdateTracker:9784526] Update Tracker - [BlackBoxEvent:3785704] DSB inducing agents induce double strand DNA breaks - v54:[addLiteratureReference, add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776079] Update Tracker - [BlackBoxEvent:3785704] DSB inducing agents induce double strand DNA breaks - v78:[modifyText] [UpdateTracker:9784526] Update Tracker - [BlackBoxEvent:3785704] DSB inducing agents induce double strand DNA breaks - v54:[addLiteratureReference, add_removeInput, modifyText]
(hasEvent)	[Pathway:R-HSA-2559586] DNA Damage/Telomere Stress Induced Senescence [Pathway:R-HSA-5693548] Sensing of DNA Double Strand Breaks
(precedingEvent)	[Reaction:R-HSA-3785768] MRN complex binds DNA double strand breaks