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Schema
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Reaction
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Entries
EPM2A dimer dephosphorylates phosphoglycogen-GYG1
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authored
[InstanceEdit:3907318] D'Eustachio, P, 2013-07-19
catalystActivity
[CatalystActivity:3781013] carbohydrate phosphatase activity of EPM2A:PPP1R3C:phosphoglycogen-GYG1:GYS1-a tetramer [cytosol]
catalystActivityReference
[CatalystActivityReference:9643985] carbohydrate phosphatase activity of EPM2A:PPP1R3C:phosphoglycogen-GYG1:GYS1-a tetramer [cytosol] Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:3781010] D'Eustachio, P, 2013-06-27
crossReference
[DatabaseIdentifier:9931471] RHEA:10685
dbId
3781018
diseaseReaction
[FailedReaction:R-HSA-3791349] Defective EPM2A does not dephosphorylate phosphoglycogen (type 2A disease) - Homo sapiens
displayName
EPM2A dimer dephosphorylates phosphoglycogen-GYG1
eventOf
[Pathway:R-HSA-3322077] Glycogen synthesis - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-3781009] NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1 - Homo sapiens
input
[Complex:R-HSA-3780999] EPM2A:PPP1R3C:phosphoglycogen-GYG1:GYS1-a tetramer [cytosol]
[SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:6805693] Structural mechanism of laforin function in glycogen dephosphorylation and lafora disease
[LiteratureReference:6805684] Dimeric quaternary structure of human laforin
[LiteratureReference:5333092] Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo
maxDepth
1
modified
[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name
EPM2A dimer dephosphorylates phosphoglycogen-GYG1
O-phospho-L-tyrosyl-(protein) + H2O => L-tyrosyl-(protein) + phosphate
orthologousEvent
[Reaction:R-SCE-3781018] EPM2A dimer dephosphorylates phosphoglycogen-GYG1 - Saccharomyces cerevisiae
[Reaction:R-CEL-3781018] EPM2A dimer dephosphorylates phosphoglycogen-GYG1 - Caenorhabditis elegans
[Reaction:R-DME-3781018] EPM2A dimer dephosphorylates phosphoglycogen-GYG1 - Drosophila melanogaster
[Reaction:R-DRE-3781018] EPM2A dimer dephosphorylates phosphoglycogen-GYG1 - Danio rerio
[Reaction:R-SSC-3781018] EPM2A dimer dephosphorylates phosphoglycogen-GYG1 - Sus scrofa
[Reaction:R-BTA-3781018] EPM2A dimer dephosphorylates phosphoglycogen-GYG1 - Bos taurus
[Reaction:R-CFA-3781018] EPM2A dimer dephosphorylates phosphoglycogen-GYG1 - Canis familiaris
[Reaction:R-RNO-3781018] EPM2A dimer dephosphorylates phosphoglycogen-GYG1 - Rattus norvegicus
[Reaction:R-MMU-3781018] EPM2A dimer dephosphorylates phosphoglycogen-GYG1 - Mus musculus
output
[Complex:R-HSA-3781000] EPM2A:PPP1R3C:glycogen-GYG1:GYS1-a tetramer [cytosol]
[SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent
[Reaction:R-HSA-3781001] EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex - Homo sapiens
releaseDate
2013-09-18
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5333091] Pederson, Bart, 2014-02-18
[InstanceEdit:4006079] Jassal, B, 2013-07-26
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-3781018
summation
[Summation:3781015] EPM2A (laforin), associated with PPP1R3C (protein phosphatas...
updateTrackers
[UpdateTracker:9786743] Update Tracker - [Reaction:3781018] EPM2A dimer dephosphorylates phosphoglycogen-GYG1 - v48:[add_removeLiteratureReference, modifyText]
[UpdateTracker:9783914] Update Tracker - [Reaction:3781018] EPM2A dimer dephosphorylates phosphoglycogen-GYG1 - v55:[addLiteratureReference, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9786743] Update Tracker - [Reaction:3781018] EPM2A dimer dephosphorylates phosphoglycogen-GYG1 - v48:[add_removeLiteratureReference, modifyText]
[UpdateTracker:9783914] Update Tracker - [Reaction:3781018] EPM2A dimer dephosphorylates phosphoglycogen-GYG1 - v55:[addLiteratureReference, modifyText]
(normalReaction)
[FailedReaction:R-HSA-3791349] Defective EPM2A does not dephosphorylate phosphoglycogen (type 2A disease)
(hasEvent)
[Pathway:R-HSA-3322077] Glycogen synthesis
(precedingEvent)
[BlackBoxEvent:R-HSA-3781009] NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1
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