Reactome | GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2

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GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 Show undefined attributes

authored	[InstanceEdit:3907318] D'Eustachio, P, 2013-07-19
catalystActivity	[CatalystActivity:3781006] glycogen synthase activity, transferring glucose-1-phosphate of PPP1R3C:glycogen-GYG2:GYS2-a tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3781010] D'Eustachio, P, 2013-06-27
dbId	3780994
displayName	GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2
eventOf	[Pathway:R-HSA-3322077] Glycogen synthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-3781021] EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG2 complex - Homo sapiens
input	[Complex:R-HSA-3777104] PPP1R3C:glycogen-GYG2:GYS2-a tetramer [cytosol] [SimpleEntity:R-ALL-29410] UDP-Glc [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6805675] Glycogen phosphomonoester distribution in mouse models of the progressive myoclonic epilepsy, Lafora disease [LiteratureReference:6805671] Muscle Glycogen Remodeling and Glycogen Phosphate Metabolism following Exhaustive Exercise of Wild Type and Laforin Knockout Mice [LiteratureReference:6805680] Hyperphosphorylation of glucosyl C6 carbons and altered structure of glycogen in the neurodegenerative epilepsy Lafora disease [LiteratureReference:3777087] Phosphate incorporation during glycogen synthesis and Lafora disease [LiteratureReference:3777107] Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG)
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2
negativePrecedingEvent	[NegativePrecedingEvent:9931470] Abundant Molecules: UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose
orthologousEvent	[Reaction:R-BTA-3780994] GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 - Bos taurus [Reaction:R-SCE-3780994] GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 - Saccharomyces cerevisiae [Reaction:R-CEL-3780994] GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 - Caenorhabditis elegans [Reaction:R-DME-3780994] GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 - Drosophila melanogaster [Reaction:R-GGA-3780994] GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 - Gallus gallus [Reaction:R-SSC-3780994] GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 - Sus scrofa [Reaction:R-CFA-3780994] GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 - Canis familiaris
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [Complex:R-HSA-3777094] PPP1R3C:phosphoglycogen-GYG2:GYS2-a tetramer [cytosol] [SimpleEntity:R-ALL-109402] UMP [cytosol]
precedingEvent	[Reaction:R-HSA-3780997] PPP1R3C binds to glycogen:GYG2:GYS2 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:5333091] Pederson, Bart, 2014-02-18 [InstanceEdit:4006079] Jassal, B, 2013-07-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3780994
summation	[Summation:3781008] Glycogen synthase 2 (GYS2) catalyzes the incorporation of ph...
updateTrackers	[UpdateTracker:9939616] Update Tracker - [Reaction:3780994] GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 - v92:[removeOutput] [UpdateTracker:9783861] Update Tracker - [Reaction:3780994] GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 - v55:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9939616] Update Tracker - [Reaction:3780994] GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 - v92:[removeOutput] [UpdateTracker:9783861] Update Tracker - [Reaction:3780994] GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 - v55:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-3322077] Glycogen synthesis
(precedingEvent)	[Reaction:R-HSA-3781021] EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG2 complex

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