Reactome | WIF1 binds WNTs

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WIF1 binds WNTs Show undefined attributes

authored	[InstanceEdit:3640727] Rothfels, K, 2013-05-29
category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:3769369] Rothfels, K, 2013-06-19
dbId	3769370
displayName	WIF1 binds WNTs
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf	[Pathway:R-HSA-3772470] Negative regulation of TCF-dependent signaling by WNT ligand antagonists - Homo sapiens
inferredFrom	[Reaction:R-MMU-3769366] Wif1 binds Wnts - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-3769320] WIF1 [extracellular region] [DefinedSet:R-HSA-3769336] WIF1-binding WNTs [extracellular region]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:3769272] Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer [LiteratureReference:3769273] Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines [LiteratureReference:3769269] Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice [LiteratureReference:3769263] WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells [LiteratureReference:3769259] The WIF domain of the human and Drosophila Wif-1 secreted factors confers specificity for Wnt or Hedgehog [LiteratureReference:3769237] Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1 [LiteratureReference:3769265] Wif-1 is expressed at cartilage-mesenchyme interfaces and impedes Wnt3a-mediated inhibition of chondrogenesis [LiteratureReference:3768849] A new secreted protein that binds to Wnt proteins and inhibits their activities [LiteratureReference:3769213] Characterization of a Wnt-binding site of the WIF-domain of Wnt inhibitory factor-1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	WIF1 binds WNTs
output	[Complex:R-HSA-3769337] WIF1:WNT [extracellular region]
precedingEvent	[Reaction:R-HSA-3247843] secretion of WNT ligands - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3769370
summation	[Summation:3769368] WNT Inhibitory factor 1 (WIF1) is a secreted antagonist of W...

Referrals

(hasEvent)	[Pathway:R-HSA-3772470] Negative regulation of TCF-dependent signaling by WNT ligand antagonists
(inferredTo)	[Reaction:R-MMU-3769366] Wif1 binds Wnts

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