Reactome | Vamp8 associated secretory vesicle to plasma membrane transport

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Vamp8 associated secretory vesicle to plasma membrane transport Show undefined attributes

authored	[InstanceEdit:434217] Gillespie, ME, 2009-08-27
catalystActivity	[CatalystActivity:376375] SNARE binding activity of Vamp8:SNAP23:Syn4 Secretory granule docking and fusion complex [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:376371] Gillespie, ME, 2008-09-06 05:38:37
dbId	376364
displayName	Vamp8 associated secretory vesicle to plasma membrane transport
eventOf	[Pathway:R-HSA-199992] trans-Golgi Network Vesicle Budding - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-376345] SNAP23 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-181519] STX4 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-376368] VAMP8 [secretory granule membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8984246] Escherichia coli exposure inhibits exocytic SNARE-mediated membrane fusion in mast cells [LiteratureReference:8863956] Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation [LiteratureReference:8984232] Allergen-sensitization increases mast-cell expression of the exocytotic proteins SNAP-23 and syntaxin 4, which are involved in histamine secretion [LiteratureReference:8984223] Ternary SNARE complexes are enriched in lipid rafts during mast cell exocytosis [LiteratureReference:8984252] Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Vamp8 associated secretory vesicle to plasma membrane transport
orthologousEvent	[Reaction:R-DDI-376364] Vamp8 associated secretory vesicle to plasma membrane transport - Dictyostelium discoideum [Reaction:R-CEL-376364] Vamp8 associated secretory vesicle to plasma membrane transport - Caenorhabditis elegans [Reaction:R-DME-376364] Vamp8 associated secretory vesicle to plasma membrane transport - Drosophila melanogaster [Reaction:R-XTR-376364] Vamp8 associated secretory vesicle to plasma membrane transport - Xenopus tropicalis [Reaction:R-DRE-376364] Vamp8 associated secretory vesicle to plasma membrane transport - Danio rerio [Reaction:R-SSC-376364] Vamp8 associated secretory vesicle to plasma membrane transport - Sus scrofa [Reaction:R-BTA-376364] Vamp8 associated secretory vesicle to plasma membrane transport - Bos taurus [Reaction:R-CFA-376364] Vamp8 associated secretory vesicle to plasma membrane transport - Canis familiaris [Reaction:R-RNO-376364] Vamp8 associated secretory vesicle to plasma membrane transport - Rattus norvegicus [Reaction:R-MMU-376364] Vamp8 associated secretory vesicle to plasma membrane transport - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-376345] SNAP23 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-181519] STX4 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-376365] VAMP8 [plasma membrane]
precedingEvent	[Reaction:R-HSA-421836] trans-Golgi Network Derived Vesicle Uncoating - Homo sapiens
releaseDate	2008-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:165091] Rush, MG, 2008-01-11 00:00:00
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-376364
summation	[Summation:376366] The vamp8 associated vesicle docks and fuses with the plasma...
updateTrackers	[UpdateTracker:9780983] Update Tracker - [Reaction:376364] Vamp8 associated secretory vesicle to plasma membrane transport - v61:[addLiteratureReference] [UpdateTracker:9791685] Update Tracker - [Reaction:376364] Vamp8 associated secretory vesicle to plasma membrane transport - v27:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9780983] Update Tracker - [Reaction:376364] Vamp8 associated secretory vesicle to plasma membrane transport - v61:[addLiteratureReference] [UpdateTracker:9791685] Update Tracker - [Reaction:376364] Vamp8 associated secretory vesicle to plasma membrane transport - v27:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-199992] trans-Golgi Network Vesicle Budding

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