Reactome | Caspase cleavage of DCC

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Caspase cleavage of DCC Show undefined attributes

authored	[InstanceEdit:373757] Garapati, P V, 2008-07-16 14:42:16
catalystActivity	[CatalystActivity:2534155] aspartic-type endopeptidase activity of Caspase-3 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643589] aspartic-type endopeptidase activity of Caspase-3 [cytosol] The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:373703] Garapati, P V, 2008-07-16 14:40:03
dbId	373705
displayName	Caspase cleavage of DCC
edited	[InstanceEdit:374705] Garapati, P V, 2008-07-30 10:24:23
eventOf	[Pathway:R-HSA-418889] Caspase activation via Dependence Receptors in the absence of ligand - Homo sapiens
followingEvent	[Reaction:R-HSA-373717] DCC interacts with DIP13alpha - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-197560] DCC [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2534128] The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis [LiteratureReference:421682] The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation [LiteratureReference:373540] Role of the dependence receptor DCC in colorectal cancer pathogenesis [LiteratureReference:373464] Netrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesis
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Caspase cleavage of DCC
orthologousEvent	[Reaction:R-DME-373705] Caspase cleavage of DCC - Drosophila melanogaster [Reaction:R-XTR-373705] Caspase cleavage of DCC - Xenopus tropicalis [Reaction:R-DRE-373705] Caspase cleavage of DCC - Danio rerio [Reaction:R-SSC-373705] Caspase cleavage of DCC - Sus scrofa [Reaction:R-BTA-373705] Caspase cleavage of DCC - Bos taurus [Reaction:R-CFA-373705] Caspase cleavage of DCC - Canis familiaris [Reaction:R-RNO-373705] Caspase cleavage of DCC - Rattus norvegicus [Reaction:R-MMU-373705] Caspase cleavage of DCC - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-373629] DCC(1291-1447) [cytosol] [EntityWithAccessionedSequence:R-HSA-373627] DCC(26-1290) [plasma membrane]
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:513006] Cooper, HM, 2010-02-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-373705
summation	[Summation:373587] DCC exerts its pro-apoptotic effect when netrin ligand is ab...
updateTrackers	[UpdateTracker:9788099] Update Tracker - [Reaction:373705] Caspase cleavage of DCC - v44:[add_removeCatalystActivity] [UpdateTracker:9788312] Update Tracker - [Reaction:373705] Caspase cleavage of DCC - v43:[addLiteratureReference, add_removeCatalystActivity, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788099] Update Tracker - [Reaction:373705] Caspase cleavage of DCC - v44:[add_removeCatalystActivity] [UpdateTracker:9788312] Update Tracker - [Reaction:373705] Caspase cleavage of DCC - v43:[addLiteratureReference, add_removeCatalystActivity, modifyText]
(hasEvent)	[Pathway:R-HSA-418889] Caspase activation via Dependence Receptors in the absence of ligand
(precedingEvent)	[Reaction:R-HSA-373717] DCC interacts with DIP13alpha

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