Reactome | Signaling by TGF-beta Receptor Complex in Cancer

Schema > Pathway > Entries

Signaling by TGF-beta Receptor Complex in Cancer Show undefined attributes

authored	[InstanceEdit:4224000] Meyer, Dominique, 2013-08-08 [InstanceEdit:4223997] Akhurst, Rosemary J, 2013-08-08 [InstanceEdit:4223999] Orlic-Milacic, M, 2013-08-08
created	[InstanceEdit:3304348] Orlic-Milacic, M, 2013-04-23
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	3304351
disease	[Disease:1500689] cancer
displayName	Signaling by TGF-beta Receptor Complex in Cancer
doi	10.3180/REACT_169122.1
edited	[InstanceEdit:4223999] Orlic-Milacic, M, 2013-08-08 [InstanceEdit:3322153] Jassal, Bijay, 2013-05-03
eventOf	[Pathway:R-HSA-5663202] Diseases of signal transduction by growth factor receptors and second messengers - Homo sapiens
figure	[Figure:9698290] /figures/ehld/R-HSA-3304351.svg
hasDiagram	true
hasEHLD	true
hasEvent	[Pathway:R-HSA-3304347] Loss of Function of SMAD4 in Cancer - Homo sapiens [Pathway:R-HSA-3304349] Loss of Function of SMAD2/3 in Cancer - Homo sapiens [Pathway:R-HSA-3642278] Loss of Function of TGFBR2 in Cancer - Homo sapiens [Pathway:R-HSA-3656534] Loss of Function of TGFBR1 in Cancer - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2020-09-24
literatureReference	[LiteratureReference:3318353] DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1 [LiteratureReference:3304374] SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer [LiteratureReference:3318554] Missense mutations of the transforming growth factor beta type II receptor in human head and neck squamous carcinoma cells [LiteratureReference:3318552] Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer [LiteratureReference:3318202] A structural basis for mutational inactivation of the tumour suppressor Smad4 [LiteratureReference:3321779] Regulation of EMT by TGF? in cancer [LiteratureReference:3642171] Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability [LiteratureReference:3640895] Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers [LiteratureReference:3697977] Reversible inhibition of normal human prokeratinocyte proliferation by type beta transforming growth factor-growth inhibitor in serum-free medium [LiteratureReference:3697993] Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism [LiteratureReference:182566] p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest [LiteratureReference:1484105] E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression [LiteratureReference:3697984] 4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation [LiteratureReference:3656346] Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1 [LiteratureReference:3662220] Transforming growth factor beta type I receptor kinase mutant associated with metastatic breast cancer [LiteratureReference:3662224] Transforming growth factor-beta receptor type I gene is frequently mutated in ovarian carcinomas [LiteratureReference:3662201] Novel inactivating mutations of transforming growth factor-beta type I receptor gene in head-and-neck cancer metastases [LiteratureReference:3697971] TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice [LiteratureReference:3697988] Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia
maxDepth	4
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Signaling by TGF-beta Receptor Complex in Cancer
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4224000] Meyer, Dominique, 2013-08-08 [InstanceEdit:4223997] Akhurst, Rosemary J, 2013-08-08
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-3304351
summation	[Summation:3318340] Signaling by the TGF-beta receptor complex is tumor suppress...
updateTrackers	[UpdateTracker:9785145] Update Tracker - [Pathway:3304351] Signaling by TGF-beta Receptor Complex in Cancer - v52:[updateContainedPathway] [UpdateTracker:9776670] Update Tracker - [Pathway:3304351] Signaling by TGF-beta Receptor Complex in Cancer - v74:[modifyText] [UpdateTracker:9777336] Update Tracker - [Pathway:3304351] Signaling by TGF-beta Receptor Complex in Cancer - v72:[updateContainedPathway] [UpdateTracker:9778548] Update Tracker - [Pathway:3304351] Signaling by TGF-beta Receptor Complex in Cancer - v68:[updateContainedPathway]

Referrals

(updatedInstance)

[UpdateTracker:9785145] Update Tracker - [Pathway:3304351] Signaling by TGF-beta Receptor Complex in Cancer - v52:[updateContainedPathway]
[UpdateTracker:9776670] Update Tracker - [Pathway:3304351] Signaling by TGF-beta Receptor Complex in Cancer - v74:[modifyText]
[UpdateTracker:9777336] Update Tracker - [Pathway:3304351] Signaling by TGF-beta Receptor Complex in Cancer - v72:[updateContainedPathway]
[UpdateTracker:9778548] Update Tracker - [Pathway:3304351] Signaling by TGF-beta Receptor Complex in Cancer - v68:[updateContainedPathway]

(hasEvent)

[Pathway:R-HSA-5663202] Diseases of signal transduction by growth factor receptors and second messengers

Cite Us!