Reactome | Defective G6PC3 does not hydrolyze glucose 6-phosphate

Schema > FailedReaction > Entries

Defective G6PC3 does not hydrolyze glucose 6-phosphate Show undefined attributes

authored	[InstanceEdit:3907318] D'Eustachio, P, 2013-07-19
catalystActivity	[CatalystActivity:9631882] glucose-6-phosphatase activity of G6PC3 mutants [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:3282875] D'Eustachio, P, 2013-04-12
crossReference	[DatabaseIdentifier:12020933] Mondo:0018542
dbId	3282876
disease	[Disease:3276564] severe congenital neutropenia
displayName	Defective G6PC3 does not hydrolyze glucose 6-phosphate
edited	[InstanceEdit:6791027] D'Eustachio, Peter, 2015-08-17
entityFunctionalStatus	[EntityFunctionalStatus:3282871] loss_of_function of G6PC3 mutants [endoplasmic reticulum membrane]
eventOf	[Pathway:R-HSA-3282872] Severe congenital neutropenia type 4 (G6PC3) - Homo sapiens
input	[SimpleEntity:R-ALL-113782] G6P [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:3262510] A syndrome with congenital neutropenia and mutations in G6PC3 [LiteratureReference:3276570] Extended spectrum of human glucose-6-phosphatase catalytic subunit 3 deficiency: novel genotypes and phenotypic variability in severe congenital neutropenia
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective G6PC3 does not hydrolyze glucose 6-phosphate
normalReaction	[Reaction:R-HSA-3262512] G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous)
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6791026] Jassal, Bijay, 2015-08-17
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3282876
summation	[Summation:3282873] Glucose-6-phosphatase 3 (G6PC3) associated with the endoplas...
updateTrackers	[UpdateTracker:9778062] Update Tracker - [FailedReaction:3282876] Defective G6PC3 does not hydrolyze glucose 6-phosphate - v68:[addCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9778062] Update Tracker - [FailedReaction:3282876] Defective G6PC3 does not hydrolyze glucose 6-phosphate - v68:[addCatalystActivity]
(hasEvent)	[Pathway:R-HSA-3282872] Severe congenital neutropenia type 4 (G6PC3)

Cite Us!