Reactome | STING recruits TBK1 and STAT6

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STING recruits TBK1 and STAT6 Show undefined attributes

authored	[InstanceEdit:2396013] Shamovsky, V, 2012-07-09
category	binding
compartment	[Compartment:70101] cytosol [Compartment:437051] cytoplasmic vesicle membrane
created	[InstanceEdit:3249381] Shamovsky, V, 2013-04-09
dbId	3249378
displayName	STING recruits TBK1 and STAT6
edited	[InstanceEdit:3465604] Shamovsky, V, 2013-05-17
eventOf	[Pathway:R-HSA-3249367] STAT6-mediated induction of chemokines - Homo sapiens
followingEvent	[Reaction:R-HSA-3249390] TBK1 is phosphorylated within STING:TBK1:STAT6 complex - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-629625] STAT6 [cytosol] [Complex:R-HSA-3134799] STING:STING [cytoplasmic vesicle membrane] 2 × [EntityWithAccessionedSequence:R-HSA-166267] TBK1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3249356] Activation of STAT6 by STING is critical for antiviral innate immunity
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	STING recruits TBK1 and STAT6
orthologousEvent	[Reaction:R-MMU-3249378] STING recruits TBK1 and STAT6 - Mus musculus [Reaction:R-DME-3249378] STING recruits TBK1 and STAT6 - Drosophila melanogaster [Reaction:R-GGA-3249378] STING recruits TBK1 and STAT6 - Gallus gallus [Reaction:R-XTR-3249378] STING recruits TBK1 and STAT6 - Xenopus tropicalis [Reaction:R-DRE-3249378] STING recruits TBK1 and STAT6 - Danio rerio [Reaction:R-SSC-3249378] STING recruits TBK1 and STAT6 - Sus scrofa [Reaction:R-BTA-3249378] STING recruits TBK1 and STAT6 - Bos taurus [Reaction:R-RNO-3249378] STING recruits TBK1 and STAT6 - Rattus norvegicus
output	[Complex:R-HSA-3249399] STING:TBK1:STAT6 [cytoplasmic vesicle membrane]
precedingEvent	[Reaction:R-HSA-3134800] STING dimerization - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3110284] D'Eustachio, P, 2013-02-11 [InstanceEdit:3597627] Jin, Lei, 2013-05-21 [InstanceEdit:3597624] Wu, Jiaxi, 2013-05-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3249378
summation	[Summation:3249363] Endogenous STAT6 was found to co-fractionate with STING from...

Referrals

(hasEvent)	[Pathway:R-HSA-3249367] STAT6-mediated induction of chemokines
(precedingEvent)	[Reaction:R-HSA-3249390] TBK1 is phosphorylated within STING:TBK1:STAT6 complex