STING recruits TBK1 and STAT6

Stable Identifier
R-HSA-3249378
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Endogenous STAT6 was found to co-fractionate with STING from the lysates of Herpes simplex virus 1 (HSV-1) - infected HeLa cells. Similar results were obtained from Sendai virus (SeV)-infected HeLa cells, where STAT6 redistributed to the perinuclear region to co-localizes with STING upon infection. Co-immunoprecipitation assays confirmed STAT6-STING interaction in human embryonic kidney HEK293 cells. The DNA-binding domain (DBD) of STAT6 and C terminus (aa 317-379) of STING were essential for this interaction. The TBK1 kinase activity was required for virus-induced STAT6 phosphorylation, however the direct interaction between STAT6 and TBK1 is not yet reported (Chen H et al. 2011). Co-immunoprecipitation assays in HEK293T cells expressing HA-tagged STING and Flag-tagged TBK1 showed that TBK directly interacts with STING (Ouyang S et al. 2012).

Literature References
PubMed ID Title Journal Year
22000020 Activation of STAT6 by STING is critical for antiviral innate immunity

Chen, H, Sun, H, You, F, Sun, W, Zhou, X, Chen, L, Yang, J, Wang, Y, Tang, H, Guan, Y, Xia, W, Gu, J, Ishikawa, H, Gutman, D, Barber, G, Qin, Z, Jiang, Z

Cell 2011
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