Reactome | MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)

Schema > Reaction > Entries

MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1) Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
catalystActivity	[CatalystActivity:3228467] protein serine/threonine kinase activity of MAP3K5 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3229148] Orlic-Milacic, M, 2013-03-26
dbId	3229152
displayName	MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
eventOf	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
inferredFrom	[Reaction:R-NUL-3299417] MAP3K5 (ASK1) phosphorylates Map2k4(Sek1) - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-168107] MAP2K4 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:3228464] Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways [LiteratureReference:3229146] Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-168170] p-S257,T261-MAP2K4 [cytosol]
precedingEvent	[Reaction:R-HSA-3225851] ROS oxidize thioredoxin and activate MAP3K5 - Homo sapiens
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3229152
summation	[Summation:3299418] MAP3K5 (ASK1) phosphorylates and activates MAP2K4 (SEK1) (Ic...

Referrals

(hasEvent)	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence
(inferredTo)	[Reaction:R-NUL-3299417] MAP3K5 (ASK1) phosphorylates Map2k4(Sek1)

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