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Schema
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Reaction
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Entries
PRMT5 binds WDR77
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authored
[InstanceEdit:3214866] Jupe, S, 2013-03-12
category
binding
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:3215411] Jupe, S, 2013-03-15
dbId
3215406
displayName
PRMT5 binds WDR77
edited
[InstanceEdit:3215411] Jupe, S, 2013-03-15
eventOf
[Pathway:R-HSA-3214858] RMTs methylate histone arginines - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-5205609] PRMT5 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-5205610] WDR77 [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:3215389] A novel WD repeat protein component of the methylosome binds Sm proteins
maxDepth
1
modified
[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name
PRMT5 binds WDR77
orthologousEvent
[Reaction:R-DDI-3215406] PRMT5 binds WDR77 - Dictyostelium discoideum
[Reaction:R-DME-3215406] PRMT5 binds WDR77 - Drosophila melanogaster
[Reaction:R-GGA-3215406] PRMT5 binds WDR77 - Gallus gallus
[Reaction:R-XTR-3215406] PRMT5 binds WDR77 - Xenopus tropicalis
[Reaction:R-SSC-3215406] PRMT5 binds WDR77 - Sus scrofa
[Reaction:R-BTA-3215406] PRMT5 binds WDR77 - Bos taurus
[Reaction:R-CFA-3215406] PRMT5 binds WDR77 - Canis familiaris
[Reaction:R-RNO-3215406] PRMT5 binds WDR77 - Rattus norvegicus
[Reaction:R-MMU-3215406] PRMT5 binds WDR77 - Mus musculus
output
[Complex:R-HSA-5205601] PRMT5:WDR77 [nucleoplasm]
regulatedBy
[NegativeRegulation:R-HSA-5212683] Negative regulation by 'p-Y297,304,307-PRMT5 [nucleoplasm]'
regulationReference
[RegulationReference:9642735] Negative regulation by 'p-Y297,304,307-PRMT5 [nucleoplasm]' JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation
releaseDate
2014-06-10
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5423560] Guccione, Ernesto, 2014-05-09
[InstanceEdit:5612458] Fischle, Wolfgang, 2014-07-23
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-3215406
summation
[Summation:3215454] In mammalian cells, PRMT5 is tightly bound by WDR77 (MEP50)....
updateTrackers
[UpdateTracker:9775783] Update Tracker - [Reaction:3215406] PRMT5 binds WDR77 - v78:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9775783] Update Tracker - [Reaction:3215406] PRMT5 binds WDR77 - v78:[modifyText]
(hasEvent)
[Pathway:R-HSA-3214858] RMTs methylate histone arginines
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