Reactome | PRMT5 binds WDR77

Schema > Reaction > Entries

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10784075
displayName	PRMT5 binds WDR77
eventOf	[Pathway:R-GGA-3214858] RMTs methylate histone arginines - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-3215406] PRMT5 binds WDR77 - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-5205609] PRMT5 [nucleoplasm] [EntityWithAccessionedSequence:R-GGA-5205610] WDR77 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PRMT5 binds WDR77
output	[Complex:R-GGA-5205601] PRMT5:WDR77 [nucleoplasm]
regulatedBy	[NegativeRegulation:10784076] Negative regulation by 'p-Y297,304,307-PRMT5 [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-3215406
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-GGA-3214858] RMTs methylate histone arginines
(inferredTo)	[Reaction:R-HSA-3215406] PRMT5 binds WDR77