Reactome | Processing and activation of SUMO

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Processing and activation of SUMO Show undefined attributes

authored	[InstanceEdit:3214927] May, B, 2013-03-10
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3214964] May, B, 2013-03-14
dbId	3215018
displayName	Processing and activation of SUMO
doi	10.3180/REACT_163793.1
edited	[InstanceEdit:3214927] May, B, 2013-03-10
eventOf	[Pathway:R-HSA-2990846] SUMOylation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:4162] protein sumoylation
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-3065679] SUMO is proteolytically processed - Homo sapiens [Pathway:R-HSA-3065676] SUMO is conjugated to E1 (UBA2:SAE1) - Homo sapiens [Pathway:R-HSA-3065678] SUMO is transferred from E1 to E2 (UBE2I, UBC9) - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:3214977] The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition [LiteratureReference:3214989] Post-translational modification by SUMO [LiteratureReference:2990841] Mechanisms, regulation and consequences of protein SUMOylation [LiteratureReference:3214935] SUMOylation and deSUMOylation at a glance [LiteratureReference:2984291] Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1 [LiteratureReference:2984315] Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1 [LiteratureReference:2984289] Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex [LiteratureReference:3299587] Association of the human SUMO-1 protease SENP2 with the nuclear pore [LiteratureReference:3299590] Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2 [LiteratureReference:3299592] The SUMO-specific protease SENP5 is required for cell division [LiteratureReference:3214974] Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs [LiteratureReference:3448676] SUMO protease SENP1 induces isomerization of the scissile peptide bond [LiteratureReference:3448666] Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates [LiteratureReference:3448697] SUMO-specific proteases: a twist in the tail
maxDepth	3
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Processing and activation of SUMO
orthologousEvent	[Pathway:R-SCE-3215018] Processing and activation of SUMO - Saccharomyces cerevisiae [Pathway:R-SPO-3215018] Processing and activation of SUMO - Schizosaccharomyces pombe [Pathway:R-DDI-3215018] Processing and activation of SUMO - Dictyostelium discoideum [Pathway:R-CEL-3215018] Processing and activation of SUMO - Caenorhabditis elegans [Pathway:R-DME-3215018] Processing and activation of SUMO - Drosophila melanogaster [Pathway:R-GGA-3215018] Processing and activation of SUMO - Gallus gallus [Pathway:R-XTR-3215018] Processing and activation of SUMO - Xenopus tropicalis [Pathway:R-DRE-3215018] Processing and activation of SUMO - Danio rerio [Pathway:R-SSC-3215018] Processing and activation of SUMO - Sus scrofa [Pathway:R-BTA-3215018] Processing and activation of SUMO - Bos taurus [Pathway:R-CFA-3215018] Processing and activation of SUMO - Canis familiaris [Pathway:R-RNO-3215018] Processing and activation of SUMO - Rattus norvegicus [Pathway:R-MMU-3215018] Processing and activation of SUMO - Mus musculus
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3448698] Garg, Amit K, 2013-05-16
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-3215018
summation	[Summation:3222560] The initial translation products of SUMO1, SUMO2, and SUMO3 ...
updateTrackers	[UpdateTracker:9775796] Update Tracker - [Pathway:3215018] Processing and activation of SUMO - v78:[updateIndirectRLE] [UpdateTracker:9782833] Update Tracker - [Pathway:3215018] Processing and activation of SUMO - v58:[updateIndirectRLE]

Referrals

(updatedInstance)	[UpdateTracker:9775796] Update Tracker - [Pathway:3215018] Processing and activation of SUMO - v78:[updateIndirectRLE] [UpdateTracker:9782833] Update Tracker - [Pathway:3215018] Processing and activation of SUMO - v58:[updateIndirectRLE]
(hasEvent)	[Pathway:R-HSA-2990846] SUMOylation

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