Reactome | DNA-PK:microbial dsDNA [cytosol]

Schema > Complex > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3134846] Shamovsky, V, 2013-02-13
crossReference	[DatabaseIdentifier:12020762] Mondo:0005108
dbId	3134811
deleted	[Deleted:9628335] Deletion of instance: 3261231
disease	[Disease:3134794] viral infectious disease
displayName	DNA-PK:microbial dsDNA [cytosol]
hasComponent	[DefinedSet:R-NUL-9013760] DNA-PK ligands [cytosol] [Complex:R-HSA-3134809] Ku70:Ku80 heterodimer [cytosol] [EntityWithAccessionedSequence:R-HSA-3134816] PRKDC [cytosol]
inDisease	true
literatureReference	[LiteratureReference:3134806] DNA-PK is a DNA sensor for IRF-3-dependent innate immunity
maxDepth	3
modified	[InstanceEdit:9013773] Shamovsky, Veronica, 2017-07-26
name	DNA-PK:microbial dsDNA
positivelyRegulates	[PositiveRegulation:9628330] Positive regulation by 'DNA-PK:microbial dsDNA [cytosol]'
producedByEvent	[Reaction:R-HSA-3134821] DNA-PK binds microbial dsDNA - Homo sapiens
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:2671785] Vaccinia virus
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-3134811
updateTrackers	[UpdateTracker:9897629] Update Tracker - [Complex:3134811] DNA-PK:microbial dsDNA [cytosol] - v62:[add_removeHasComponent, removeDisease] [UpdateTracker:9886087] Update Tracker - [Complex:3134811] DNA-PK:microbial dsDNA [cytosol] - v45:[addDisease, removeSpecies]

(updatedInstance)	[UpdateTracker:9897629] Update Tracker - [Complex:3134811] DNA-PK:microbial dsDNA [cytosol] - v62:[add_removeHasComponent, removeDisease] [UpdateTracker:9886087] Update Tracker - [Complex:3134811] DNA-PK:microbial dsDNA [cytosol] - v45:[addDisease, removeSpecies]
(replacementInstances)	[Deleted:9628335] Deletion of instance: 3261231
(output)	[Reaction:R-HSA-3134821] DNA-PK binds microbial dsDNA
(regulator)	[PositiveRegulation:9628330] Positive regulation by 'DNA-PK:microbial dsDNA [cytosol]'