Reactome | PLK1 phosphorylates BORA

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PLK1 phosphorylates BORA Show undefined attributes

authored	[InstanceEdit:3004457] Orlic-Milacic, M, 2013-01-28
catalystActivity	[CatalystActivity:3000326] protein serine/threonine kinase activity of p-7S,2T-BORA:p-T210-PLK1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643264] protein serine/threonine kinase activity of p-S252-BORA:p-T210-PLK1 [cytosol] Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3000329] Orlic-Milacic, M, 2013-01-24
dbId	3000327
displayName	PLK1 phosphorylates BORA
edited	[InstanceEdit:3006289] Orlic-Milacic, M, 2013-01-29
eventOf	[Pathway:R-HSA-2565942] Regulation of PLK1 Activity at G2/M Transition - Homo sapiens
followingEvent	[Reaction:R-HSA-2172194] Recruitment of PLK1 to phosphorylated GORASP1 (GRASP65) - Homo sapiens [Reaction:R-HSA-156682] PLK1 phosphorylates NUDC - Homo sapiens [Reaction:R-HSA-3000339] Phosphorylated BORA binds SCF-beta-TrCp1/2 - Homo sapiens [Reaction:R-HSA-3002798] Cytosolic PLK1 translocates to the nucleus - Homo sapiens [Reaction:R-HSA-2984226] PLK1 phosphorylates NEK9 - Homo sapiens [Reaction:R-HSA-1638803] Phosphorylation of cohesin by PLK1 at centromeres - Homo sapiens [Reaction:R-HSA-2466068] Phosphorylation of cohesin by PLK1 at chromosomal arms - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-3000305] p-7S,2T-BORA:p-T210-PLK1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3000332] Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PLK1 phosphorylates BORA
orthologousEvent	[Reaction:R-CEL-3000327] PLK1 phosphorylates BORA - Caenorhabditis elegans [Reaction:R-DME-3000327] PLK1 phosphorylates BORA - Drosophila melanogaster [Reaction:R-GGA-3000327] PLK1 phosphorylates BORA - Gallus gallus [Reaction:R-XTR-3000327] PLK1 phosphorylates BORA - Xenopus tropicalis [Reaction:R-DRE-3000327] PLK1 phosphorylates BORA - Danio rerio [Reaction:R-SSC-3000327] PLK1 phosphorylates BORA - Sus scrofa [Reaction:R-BTA-3000327] PLK1 phosphorylates BORA - Bos taurus [Reaction:R-CFA-3000327] PLK1 phosphorylates BORA - Canis familiaris [Reaction:R-RNO-3000327] PLK1 phosphorylates BORA - Rattus norvegicus [Reaction:R-MMU-3000327] PLK1 phosphorylates BORA - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-3000330] p-8S,3T-BORA [cytosol] [EntityWithAccessionedSequence:R-HSA-3000318] p-T210-PLK1 [cytosol]
precedingEvent	[Reaction:R-HSA-3000310] AURKA phosphorylates PLK1 - Homo sapiens
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4410473] Bruinsma, Wytse, 2013-08-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3000327
summation	[Summation:3002842] PLK1 phosphorylates BORA on serine residue S497 and threonin...

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[Pathway:R-HSA-2565942] Regulation of PLK1 Activity at G2/M Transition

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