PLK1 phosphorylates BORA

Stable Identifier
R-HSA-3000327
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PLK1 phosphorylates BORA on serine residue S497 and threonine residue T501 that both lie in the DSGYNT degron recognized by beta-TrCP F-box proteins (Seki et al. 2008).

Literature References
PubMed ID Title Journal Year
18378770 Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression

Seki, A, Coppinger, JA, Yates, JR, Jang, CY, Fang, G, Du, H

J. Cell Biol. 2008
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-S252-BORA:p-T210-PLK1 [cytosol]

Orthologous Events
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