PLK1 phosphorylates BORA

Stable Identifier
R-HSA-3000327
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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PLK1 phosphorylates BORA
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PLK1 phosphorylates BORA on serine residue S497 and threonine residue T501 that both lie in the DSGYNT degron recognized by beta-TrCP F-box proteins (Seki et al. 2008).

Literature References
PubMed ID Title Journal Year
18378770 Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression

Seki, A, Coppinger, JA, Du, H, Jang, CY, Yates, JR, Fang, G

J. Cell Biol. 2008
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S252-BORA:p-T210-PLK1 [cytosol]
Physical Entity
p-S252-BORA:p-T210-PLK1 [cytosol]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
PLK1 phosphorylates BORA (Caenorhabditis elegans)
PLK1 phosphorylates BORA (Canis familiaris)
PLK1 phosphorylates BORA (Danio rerio)
PLK1 phosphorylates BORA (Drosophila melanogaster)
PLK1 phosphorylates BORA (Gallus gallus)
PLK1 phosphorylates BORA (Mus musculus)
PLK1 phosphorylates BORA (Rattus norvegicus)
PLK1 phosphorylates BORA (Sus scrofa)
PLK1 phosphorylates BORA (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2013-01-29)
Reviewed
Bruinsma, W  (2013-08-21)
Created
Orlic-Milacic, M  (2013-01-25)
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