Reactome | AKRs reduce RBP2:atRAL to RBP2:atROL

Schema > Reaction > Entries

AKRs reduce RBP2:atRAL to RBP2:atROL Show undefined attributes

authored	[InstanceEdit:2855255] Jassal, B, 2012-12-18
catalystActivity	[CatalystActivity:2855235] alcohol dehydrogenase (NADP+) activity of AKRs [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2855255] Jassal, B, 2012-12-18
dbId	2855252
displayName	AKRs reduce RBP2:atRAL to RBP2:atROL
edited	[InstanceEdit:2855255] Jassal, B, 2012-12-18
eventOf	[Pathway:R-HSA-975634] Retinoid metabolism and transport - Homo sapiens
followingEvent	[Reaction:R-HSA-975608] LRAT esterifies RBP2:atROL and FACYLs to atREs - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [Complex:R-HSA-975639] RBP2:atRAL [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2855248] Aldo-keto reductases from the AKR1B subfamily: retinoid specificity and control of cellular retinoic acid levels [LiteratureReference:2855239] Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily [LiteratureReference:2855251] Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	AKRs reduce RBP2:atRAL to RBP2:atROL
orthologousEvent	[Reaction:R-CEL-2855252] AKRs reduce RBP2:atRAL to RBP2:atROL - Caenorhabditis elegans [Reaction:R-DME-2855252] AKRs reduce RBP2:atRAL to RBP2:atROL - Drosophila melanogaster [Reaction:R-GGA-2855252] AKRs reduce RBP2:atRAL to RBP2:atROL - Gallus gallus [Reaction:R-XTR-2855252] AKRs reduce RBP2:atRAL to RBP2:atROL - Xenopus tropicalis [Reaction:R-DRE-2855252] AKRs reduce RBP2:atRAL to RBP2:atROL - Danio rerio [Reaction:R-SSC-2855252] AKRs reduce RBP2:atRAL to RBP2:atROL - Sus scrofa [Reaction:R-BTA-2855252] AKRs reduce RBP2:atRAL to RBP2:atROL - Bos taurus [Reaction:R-CFA-2855252] AKRs reduce RBP2:atRAL to RBP2:atROL - Canis familiaris [Reaction:R-RNO-2855252] AKRs reduce RBP2:atRAL to RBP2:atROL - Rattus norvegicus [Reaction:R-MMU-2855252] AKRs reduce RBP2:atRAL to RBP2:atROL - Mus musculus
output	[SimpleEntity:R-ALL-29366] NADP+ [cytosol] [Complex:R-HSA-975626] RBP2:atROL [cytosol]
precedingEvent	[Reaction:R-HSA-2399913] atRAL binds to RBP2 - Homo sapiens
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3006584] Blaner, William S, 2013-01-31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2855252
summation	[Summation:2855257] RDH11 is the best-characterised enzyme that reduces all-tran...

Referrals

(hasEvent)	[Pathway:R-HSA-975634] Retinoid metabolism and transport
(precedingEvent)	[Reaction:R-HSA-975608] LRAT esterifies RBP2:atROL and FACYLs to atREs