AKRs reduce RBP2:atRAL to RBP2:atROL

Stable Identifier
Reaction [transition]
Homo sapiens
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RDH11 is the best-characterised enzyme that reduces all-trans-retinal (atRAL) to all-trans-retinol (atROL). In addition, several aldo-keto reductase (AKR) enzymes from subfamilies 1B and 1C also show all-trans-retinal (atRAL) reductase activity. AKR1B10 shows high reductase activity towards atRAL (Gallego et al. 2007, Ruiz et al. 2009) whereas AKR1C1, 1C3 and 1C4 all show much lower reductase activity towards arRAL (Ruiz et al. 2011).

Literature References
PubMed ID Title Journal Year
19014918 Aldo-keto reductases from the AKR1B subfamily: retinoid specificity and control of cellular retinoic acid levels

Ruiz, FX, Gallego, O, Ardèvol, A, Moro, A, Domínguez, M, Alvarez, S, Alvarez, R, de Lera, AR, Rovira, C, Fita, I, Parés, X, Farrés, J

Chem. Biol. Interact. 2009
21851338 Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily

Ruiz, FX, Porté, S, Gallego, O, Moro, A, Ardèvol, A, Del Río-Espínola, A, Rovira, C, Farrés, J, Parés, X

Biochem. J. 2011
18087047 Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10

Gallego, O, Ruiz, FX, Ardèvol, A, Domínguez, M, Alvarez, R, de Lera, AR, Rovira, C, Farrés, J, Fita, I, Parés, X

Proc. Natl. Acad. Sci. U.S.A. 2007
Catalyst Activity

aldo-keto reductase (NADP) activity of AKRs [cytosol]

Orthologous Events
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