Reactome | PI3K associates with phosphorylated GAB2

Schema > Reaction > Entries

PI3K associates with phosphorylated GAB2 Show undefined attributes

authored	[InstanceEdit:2871799] Niarakis, Anna, 2012-12-21
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2730834] Garapati, P V, 2012-12-05
dbId	2730842
displayName	PI3K associates with phosphorylated GAB2
edited	[InstanceEdit:2454233] Garapati, P V, 2012-08-22
eventOf	[Pathway:R-HSA-2730905] Role of LAT2/NTAL/LAB on calcium mobilization - Homo sapiens
followingEvent	[Reaction:R-HSA-2730870] Phosphorylation of PIP2 to PIP3 by PI3K - Homo sapiens
input	[Complex:R-HSA-2685687] p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] [Complex:R-HSA-74693] PI3K [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2685029] Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors [LiteratureReference:2685355] Gab2, via PI-3K, regulates ARF1 in Fc?RI-mediated granule translocation and mast cell degranulation [LiteratureReference:2685026] Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	PI3K associates with phosphorylated GAB2
orthologousEvent	[Reaction:R-DME-2730842] PI3K associates with phosphorylated GAB2 - Drosophila melanogaster [Reaction:R-GGA-2730842] PI3K associates with phosphorylated GAB2 - Gallus gallus [Reaction:R-XTR-2730842] PI3K associates with phosphorylated GAB2 - Xenopus tropicalis [Reaction:R-SSC-2730842] PI3K associates with phosphorylated GAB2 - Sus scrofa [Reaction:R-BTA-2730842] PI3K associates with phosphorylated GAB2 - Bos taurus [Reaction:R-CFA-2730842] PI3K associates with phosphorylated GAB2 - Canis familiaris [Reaction:R-RNO-2730842] PI3K associates with phosphorylated GAB2 - Rattus norvegicus [Reaction:R-MMU-2730842] PI3K associates with phosphorylated GAB2 - Mus musculus
output	[Complex:R-HSA-2685700] p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane]
precedingEvent	[Reaction:R-HSA-2730860] Phosphorylation of GAB2 by SYK/FYN - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3139040] Roncagalli, Romain, 2013-02-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2730842
summation	[Summation:2685553] Phosphorylated Y452, Y476, and Y584 of GAB2 binds p85 regula...

Referrals

(hasEvent)	[Pathway:R-HSA-2730905] Role of LAT2/NTAL/LAB on calcium mobilization
(precedingEvent)	[Reaction:R-HSA-2730870] Phosphorylation of PIP2 to PIP3 by PI3K