Reactome | Caspase-mediated cleavage of Lamin A

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Caspase-mediated cleavage of Lamin A Show undefined attributes

authored	[InstanceEdit:352235] Schulze-Osthoff, K, 2008-05-18 10:00:05
catalystActivity	[CatalystActivity:352254] cysteine-type endopeptidase activity of active caspase-6 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm [Compartment:13231] nuclear envelope
created	[InstanceEdit:264863] Matthews, L, 2008-04-13 23:12:20
dbId	264865
displayName	Caspase-mediated cleavage of Lamin A
edited	[InstanceEdit:264864] Matthews, L, 2008-04-13 23:06:00 [InstanceEdit:352239] Matthews, L, 2008-06-02 07:41:19
eventOf	[Pathway:R-HSA-352238] Breakdown of the nuclear lamina - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-264866] Lamin A [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:352250] Characterization of the execution phase of apoptosis in vitro using extracts from condemned-phase cells [LiteratureReference:352258] The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Caspase-mediated cleavage of Lamin A
orthologousEvent	[Reaction:R-DME-264865] Caspase-mediated cleavage of Lamin A - Drosophila melanogaster [Reaction:R-XTR-264865] Caspase-mediated cleavage of Lamin A - Xenopus tropicalis [Reaction:R-DRE-264865] Caspase-mediated cleavage of Lamin A - Danio rerio [Reaction:R-SSC-264865] Caspase-mediated cleavage of Lamin A - Sus scrofa [Reaction:R-BTA-264865] Caspase-mediated cleavage of Lamin A - Bos taurus [Reaction:R-CFA-264865] Caspase-mediated cleavage of Lamin A - Canis familiaris [Reaction:R-RNO-264865] Caspase-mediated cleavage of Lamin A - Rattus norvegicus [Reaction:R-MMU-264865] Caspase-mediated cleavage of Lamin A - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-352253] LMNA(1-230) [nuclear envelope] [EntityWithAccessionedSequence:R-HSA-352249] LMNA(231-664) [nuclear envelope]
precedingEvent	[BlackBoxEvent:R-HSA-9029690] Caspase-6 translocates to the nucleus - Homo sapiens
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:350641] Ranganathan, S, 2008-06-11 19:13:33
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-264865
summation	[Summation:352241] Caspases initiate the destruction of the nucleus cleavage of...

Referrals

(hasEvent)

[Pathway:R-HSA-352238] Breakdown of the nuclear lamina