Reactome | Caspase-mediated cleavage of Lamin A

Caspase-mediated cleavage of Lamin A

Stable Identifier

R-HSA-264865

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm, nuclear envelope

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Caspases initiate the destruction of the nucleus cleavage of lamins leads to
disassembly of the nuclear lamina. Lamin A is cleaved by active caspase 6 (Orth et al., 1996).

Literature References

PubMed ID	Title	Journal	Year
8663580	The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A Orth, K, Chinnaiyan, AM, Garg, M, Froelich, CJ, Dixit, VM	J Biol Chem	1996
8655646	Characterization of the execution phase of apoptosis in vitro using extracts from condemned-phase cells Lazebnik, YA, Takahashi, A, Poirier, GG, Kaufmann, SH, Earnshaw, WC	J Cell Sci Suppl	1995