Reactome | Caspase-mediated cleavage of Lamin A

Caspase-mediated cleavage of Lamin A

Stable Identifier

R-HSA-264865

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm, nuclear envelope

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Caspases initiate the destruction of the nucleus cleavage of lamins leads to
disassembly of the nuclear lamina. Lamin A is cleaved by active caspase 6 (Orth et al., 1996).

Literature References

PubMed ID	Title	Journal	Year
8655646	Characterization of the execution phase of apoptosis in vitro using extracts from condemned-phase cells Earnshaw, WC, Takahashi, A, Lazebnik, YA, Kaufmann, SH, Poirier, GG	J Cell Sci Suppl	1995
8663580	The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A Dixit, VM, Froelich, CJ, Garg, M, Chinnaiyan, AM, Orth, K	J Biol Chem	1996