Caspase-mediated cleavage of Lamin A

Stable Identifier
R-HSA-264865
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm, nuclear envelope
ReviewStatus
5/5
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Caspase-mediated cleavage of Lamin A
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Caspases initiate the destruction of the nucleus cleavage of lamins leads to
disassembly of the nuclear lamina. Lamin A is cleaved by active caspase 6 (Orth et al., 1996).
Literature References
PubMed ID Title Journal Year
8655646 Characterization of the execution phase of apoptosis in vitro using extracts from condemned-phase cells

Lazebnik, YA, Takahashi, A, Poirier, GG, Kaufmann, SH, Earnshaw, WC

J Cell Sci Suppl 1995
8663580 The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A

Orth, K, Chinnaiyan, AM, Garg, M, Froelich, CJ, Dixit, VM

J Biol Chem 1996
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type endopeptidase activity of active caspase-6 [nucleoplasm]

Physical Entity
active caspase-6 [nucleoplasm] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Caspase-mediated cleavage of Lamin A (Bos taurus)
Caspase-mediated cleavage of Lamin A (Canis familiaris)
Caspase-mediated cleavage of Lamin A (Danio rerio)
Caspase-mediated cleavage of Lamin A (Drosophila melanogaster)
Caspase-mediated cleavage of Lamin A (Mus musculus)
Caspase-mediated cleavage of Lamin A (Rattus norvegicus)
Caspase-mediated cleavage of Lamin A (Sus scrofa)
Caspase-mediated cleavage of Lamin A (Xenopus tropicalis)
Authored
Schulze-Osthoff, K  (2008-05-18)
Reviewed
Ranganathan, S  (2008-06-11)
Created
Matthews, L  (2008-04-14)
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