Caspase-mediated cleavage of Lamin A

Stable Identifier
R-HSA-264865
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Caspases initiate the destruction of the nucleus cleavage of lamins leads to
disassembly of the nuclear lamina. Lamin A is cleaved by active caspase 6 (Orth et al., 1996).
Literature References
PubMed ID Title Journal Year
8655646 Characterization of the execution phase of apoptosis in vitro using extracts from condemned-phase cells

Earnshaw, WC, Takahashi, A, Lazebnik, YA, Kaufmann, SH, Poirier, GG

J Cell Sci Suppl 1995
8663580 The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A

Dixit, VM, Froelich, CJ, Garg, M, Chinnaiyan, AM, Orth, K

J Biol Chem 1996
Participants
Participates
Catalyst Activity

cysteine-type endopeptidase activity of active caspase-6 [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
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