Caspase-mediated cleavage of Lamin A

Stable Identifier
R-HSA-264865
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Caspases initiate the destruction of the nucleus cleavage of lamins leads to
disassembly of the nuclear lamina. Lamin A is cleaved by active caspase 6 (Orth et al., 1996).

Literature References
PubMed ID Title Journal Year
8663580 The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A

Orth, K, Chinnaiyan, AM, Garg, M, Froelich, CJ, Dixit, VM

J Biol Chem 1996
8655646 Characterization of the execution phase of apoptosis in vitro using extracts from condemned-phase cells

Lazebnik, YA, Takahashi, A, Poirier, GG, Kaufmann, SH, Earnshaw, WC

J Cell Sci Suppl 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of active caspase-6 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created