Reactome | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling

Schema > Pathway > Entries

authored	[InstanceEdit:2958607] Orlic-Milacic, M, 2013-01-04
created	[InstanceEdit:2644604] Orlic-Milacic, M, 2012-11-21
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	2644607
disease	[Disease:1500689] cancer
displayName	Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
edited	[InstanceEdit:2980626] Jassal, B, 2013-01-09
eventOf	[Pathway:R-HSA-2644605] FBXW7 Mutants and NOTCH1 in Cancer - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-2220978] FBXW7 WD mutants do not bind NICD1 - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1602315] FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors [LiteratureReference:1602435] The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia [LiteratureReference:2870239] Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase [LiteratureReference:351516] Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
releaseDate	2012-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3110296] Haw, R, 2013-02-10
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2644607
summation	[Summation:2892464] Loss of function mutations found in FBXW7 in T-cell acute ly...

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