Reactome | FBXW7 Mutants and NOTCH1 in Cancer

Schema > Pathway > Entries

FBXW7 Mutants and NOTCH1 in Cancer Show undefined attributes

authored	[InstanceEdit:2958607] Orlic-Milacic, M, 2013-01-04
created	[InstanceEdit:2644604] Orlic-Milacic, M, 2012-11-21
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	2644605
disease	[Disease:1500689] cancer
displayName	FBXW7 Mutants and NOTCH1 in Cancer
edited	[InstanceEdit:2980626] Jassal, B, 2013-01-09
eventOf	[Pathway:R-HSA-2644603] Signaling by NOTCH1 in Cancer - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-2644607] Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2015-03-23
literatureReference	[LiteratureReference:2064850] The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog [LiteratureReference:2064869] SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation [LiteratureReference:351516] Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover [LiteratureReference:2870255] FBXW7/hCDC4 is a general tumor suppressor in human cancer [LiteratureReference:1602435] The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia [LiteratureReference:1602315] FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
maxDepth	3
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	FBXW7 Mutants and NOTCH1 in Cancer
normalPathway	[Pathway:R-HSA-1980143] Signaling by NOTCH1
releaseDate	2012-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3110296] Haw, R, 2013-02-10
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2644605
summation	[Summation:2892461] FBXW7 (FBW7) is a component of the SCF (SKP1, CUL1, and F-bo...
updateTrackers	[UpdateTracker:9785468] Update Tracker - [Pathway:2644605] FBXW7 Mutants and NOTCH1 in Cancer - v52:[removeHasEvent] [UpdateTracker:9787076] Update Tracker - [Pathway:2644605] FBXW7 Mutants and NOTCH1 in Cancer - v46:[updateContainedPathway]

Referrals

(updatedInstance)	[UpdateTracker:9785468] Update Tracker - [Pathway:2644605] FBXW7 Mutants and NOTCH1 in Cancer - v52:[removeHasEvent] [UpdateTracker:9787076] Update Tracker - [Pathway:2644605] FBXW7 Mutants and NOTCH1 in Cancer - v46:[updateContainedPathway]
(hasEvent)	[Pathway:R-HSA-2644603] Signaling by NOTCH1 in Cancer