Reactome | RIP3 binds TRIF to mediate necroptosis

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RIP3 binds TRIF to mediate necroptosis Show undefined attributes

authored	[InstanceEdit:2248861] Shamovsky, V, 2012-05-15
category	transition
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:2569056] Shamovsky, V, 2012-11-12
dbId	2569057
displayName	RIP3 binds TRIF to mediate necroptosis
edited	[InstanceEdit:2603274] Shamovsky, V, 2012-11-19
eventOf	[Pathway:R-HSA-2562578] TRIF-mediated programmed cell death - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:396762] necroptotic process
input	4 × [EntityWithAccessionedSequence:R-HSA-450328] RIPK3 [cytosol] [CandidateSet:R-HSA-2569052] TRIF:activated TLR4 [endosome membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2584548] Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA [LiteratureReference:2584557] Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway [LiteratureReference:2562551] cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms [LiteratureReference:936978] Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	RIP3 binds TRIF to mediate necroptosis
orthologousEvent	[Reaction:R-SSC-2569057] RIP3 binds TRIF to mediate necroptosis - Sus scrofa [Reaction:R-BTA-2569057] RIP3 binds TRIF to mediate necroptosis - Bos taurus [Reaction:R-CFA-2569057] RIP3 binds TRIF to mediate necroptosis - Canis familiaris [Reaction:R-RNO-2569057] RIP3 binds TRIF to mediate necroptosis - Rattus norvegicus [Reaction:R-MMU-2569057] RIP3 binds TRIF to mediate necroptosis - Mus musculus
output	[CandidateSet:R-HSA-2569055] RIP3:TICAM1:activated TLR4 [endosome membrane]
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2569057
summation	[Summation:2584542] TLR3 and TLR4 -directed programmed necrosis (necroptosis) is...

Referrals

(hasEvent)

[Pathway:R-HSA-2562578] TRIF-mediated programmed cell death