Reactome | RIP3 binds TRIF to mediate necroptosis

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RIP3 binds TRIF to mediate necroptosis Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10390033
displayName	RIP3 binds TRIF to mediate necroptosis
eventOf	[Pathway:R-BTA-2562578] TRIF-mediated programmed cell death - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:396762] necroptotic process
inferredFrom	[Reaction:R-HSA-2569057] RIP3 binds TRIF to mediate necroptosis - Homo sapiens
input	4 × [EntityWithAccessionedSequence:R-BTA-450328] RIPK3 [cytosol] [CandidateSet:R-BTA-2569052] TRIF:activated TLR4 [endosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	RIP3 binds TRIF to mediate necroptosis
output	[CandidateSet:R-BTA-2569055] RIP3:TICAM1:activated TLR4 [endosome membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-2569057
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-2562578] TRIF-mediated programmed cell death
(inferredTo)	[Reaction:R-HSA-2569057] RIP3 binds TRIF to mediate necroptosis

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