Reactome | Cellular Senescence

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Cellular Senescence Show undefined attributes

authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
created	[InstanceEdit:2559581] Orlic-Milacic, M, 2012-11-02
dbId	2559583
displayName	Cellular Senescence
doi	10.3180/REACT_169274.2
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
eventOf	[Pathway:R-HSA-2262752] Cellular responses to stress - Homo sapiens
figure	[Figure:9628902] /figures/ehld/R-HSA-2559583.svg
goBiologicalProcess	[GO_BiologicalProcess:1221407] cellular senescence
hasDiagram	true
hasEHLD	true
hasEvent	[Pathway:R-HSA-2559585] Oncogene Induced Senescence - Homo sapiens [Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens [Pathway:R-HSA-2559586] DNA Damage/Telomere Stress Induced Senescence - Homo sapiens [Pathway:R-HSA-2559582] Senescence-Associated Secretory Phenotype (SASP) - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:3245921] Cellular senescence in cancer and aging [LiteratureReference:3245917] Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence [LiteratureReference:3245922] The essence of senescence [LiteratureReference:3899334] Cellular senescence: when bad things happen to good cells [LiteratureReference:4608704] The biology of replicative senescence [LiteratureReference:4608711] The hallmarks of aging [LiteratureReference:4608715] Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders [LiteratureReference:4608718] The serial cultivation of human diploid cell strains [LiteratureReference:4608726] Critical pathways in cellular senescence and immortalization revealed by gene expression profiling [LiteratureReference:3877072] Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor [LiteratureReference:3877107] Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion [LiteratureReference:3857340] Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network [LiteratureReference:3877102] Chemokine signaling via the CXCR2 receptor reinforces senescence
maxDepth	4
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Cellular Senescence
orthologousEvent	[Pathway:R-MMU-2559583] Cellular Senescence - Mus musculus [Pathway:R-RNO-2559583] Cellular Senescence - Rattus norvegicus [Pathway:R-CFA-2559583] Cellular Senescence - Canis familiaris [Pathway:R-BTA-2559583] Cellular Senescence - Bos taurus [Pathway:R-SSC-2559583] Cellular Senescence - Sus scrofa [Pathway:R-DRE-2559583] Cellular Senescence - Danio rerio [Pathway:R-XTR-2559583] Cellular Senescence - Xenopus tropicalis [Pathway:R-GGA-2559583] Cellular Senescence - Gallus gallus [Pathway:R-DME-2559583] Cellular Senescence - Drosophila melanogaster [Pathway:R-CEL-2559583] Cellular Senescence - Caenorhabditis elegans [Pathway:R-DDI-2559583] Cellular Senescence - Dictyostelium discoideum [Pathway:R-SPO-2559583] Cellular Senescence - Schizosaccharomyces pombe [Pathway:R-SCE-2559583] Cellular Senescence - Saccharomyces cerevisiae [Pathway:R-PFA-2559583] Cellular Senescence - Plasmodium falciparum
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
revised	[InstanceEdit:4648961] Orlic-Milacic, M, 2013-09-30
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2559583
summation	[Summation:3245919] Cellular senescence involves irreversible growth arrest acco...
updateTrackers	[UpdateTracker:9784015] Update Tracker - [Pathway:2559583] Cellular Senescence - v55:[updateIndirectRLE] [UpdateTracker:9782979] Update Tracker - [Pathway:2559583] Cellular Senescence - v58:[updateContainedPathway] [UpdateTracker:9780043] Update Tracker - [Pathway:2559583] Cellular Senescence - v64:[updateIndirectRLE] [UpdateTracker:9782005] Update Tracker - [Pathway:2559583] Cellular Senescence - v60:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9786543] Update Tracker - [Pathway:2559583] Cellular Senescence - v49:[modifyText] [UpdateTracker:9784107] Update Tracker - [Pathway:2559583] Cellular Senescence - v54:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9778901] Update Tracker - [Pathway:2559583] Cellular Senescence - v67:[updateIndirectRLE] [UpdateTracker:9782168] Update Tracker - [Pathway:2559583] Cellular Senescence - v59:[updateIndirectRLE] [UpdateTracker:9783604] Update Tracker - [Pathway:2559583] Cellular Senescence - v56:[updateIndirectRLE] [UpdateTracker:9775849] Update Tracker - [Pathway:2559583] Cellular Senescence - v78:[updateIndirectRLE] [UpdateTracker:9786953] Update Tracker - [Pathway:2559583] Cellular Senescence - v47:[addLiteratureReference, modifyText, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9784721] Update Tracker - [Pathway:2559583] Cellular Senescence - v53:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9777620] Update Tracker - [Pathway:2559583] Cellular Senescence - v70:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9777798] Update Tracker - [Pathway:2559583] Cellular Senescence - v69:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783026] Update Tracker - [Pathway:2559583] Cellular Senescence - v57:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9777473] Update Tracker - [Pathway:2559583] Cellular Senescence - v71:[updateIndirectRLE] [UpdateTracker:9780544] Update Tracker - [Pathway:2559583] Cellular Senescence - v62:[addLiteratureReference, modifyText, updateIndirectRLE]

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[Pathway:R-HSA-2262752] Cellular responses to stress

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