Reactome | TLR1:TLR2 ligand:CD14 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-181226] TLR1:TLR2:TLR1/2 ligand:CD14 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-168951] TLR1:TLR2 is recruited to ligand:CD14 - Homo sapiens
created	[InstanceEdit:2559467] Shamovsky, V, 2012-11-02
dbId	2559462
displayName	TLR1:TLR2 ligand:CD14 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-HSA-166033] GPIN-CD14(20-345) [plasma membrane] [DefinedSet:R-NME-168944] TLR1:TLR2 recognized ligand [extracellular region]
inDisease	false
includedLocation	[Compartment:984] extracellular region
literatureReference	[LiteratureReference:2428886] Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting [LiteratureReference:2559436] Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1
maxDepth	4
modified	[InstanceEdit:8959586] Weiser, JD
name	TLR1:TLR2 ligand:CD14
producedByEvent	[Reaction:R-HSA-2559468] TLR1/2 ligand binds to CD14 - Homo sapiens
relatedSpecies	[Species:180800] Neisseria meningitidis serogroup B
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-2559462
updateTrackers	[UpdateTracker:9896260] Update Tracker - [Complex:2559462] TLR1:TLR2 ligand:CD14 [plasma membrane] - v60:[removeSpecies]

(updatedInstance)	[UpdateTracker:9896260] Update Tracker - [Complex:2559462] TLR1:TLR2 ligand:CD14 [plasma membrane] - v60:[removeSpecies]
(output)	[Reaction:R-HSA-2559468] TLR1/2 ligand binds to CD14
(input)	[Reaction:R-HSA-168951] TLR1:TLR2 is recruited to ligand:CD14
(hasComponent)	[Complex:R-HSA-181226] TLR1:TLR2:TLR1/2 ligand:CD14 [plasma membrane]

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