Reactome | CatSper Channel Mediated Calcium Transport

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CatSper Channel Mediated Calcium Transport Show undefined attributes

authored	[InstanceEdit:3132742] Gillespie, ME, 2013-02-12
catalystActivity	[CatalystActivity:2534341] calcium ion transmembrane transporter activity of Activated CatSper Channel [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2534342] Gillespie, ME, 2012-10-25
crossReference	[DatabaseIdentifier:12667421] RHEA:29671
dbId	2534359
displayName	CatSper Channel Mediated Calcium Transport
edited	[InstanceEdit:3611336] Gillespie, ME, 2013-05-23
eventOf	[Pathway:R-HSA-1300642] Sperm Motility And Taxes - Homo sapiens
followingEvent	[Reaction:R-HSA-2534378] Hv1 Mediated H+ Permeability - Homo sapiens [Reaction:R-HSA-2534365] Slo3 Potassium Transport - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:264018] response to progesterone
input	[SimpleEntity:R-ALL-74112] Ca2+ [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2534367] Genetic male infertility and mutation of CATSPER ion channels [LiteratureReference:3595164] A sperm ion channel required for sperm motility and male fertility [LiteratureReference:3595157] All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility [LiteratureReference:3595149] Disruption of the principal, progesterone-activated sperm Ca2+ channel in a CatSper2-deficient infertile patient [LiteratureReference:2534384] Progesterone activates the principal Ca2+ channel of human sperm
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	CatSper Channel Mediated Calcium Transport
orthologousEvent	[Reaction:R-SSC-2534359] CatSper Channel Mediated Calcium Transport - Sus scrofa [Reaction:R-BTA-2534359] CatSper Channel Mediated Calcium Transport - Bos taurus [Reaction:R-CFA-2534359] CatSper Channel Mediated Calcium Transport - Canis familiaris [Reaction:R-RNO-2534359] CatSper Channel Mediated Calcium Transport - Rattus norvegicus [Reaction:R-MMU-2534359] CatSper Channel Mediated Calcium Transport - Mus musculus
output	[SimpleEntity:R-ALL-74016] Ca2+ [cytosol]
precedingEvent	[Reaction:R-HSA-2534388] Progesterone Activation Of CatSper - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3595169] Lishko, Polina V, 2013-05-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2534359
summation	[Summation:2534333] CatSper (CATionic channel of SPERm), a pH regulated, princip...

Referrals

(precedingEvent)	[Reaction:R-HSA-2534378] Hv1 Mediated H+ Permeability [Reaction:R-HSA-2534365] Slo3 Potassium Transport
(hasEvent)	[Pathway:R-HSA-1300642] Sperm Motility And Taxes

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