Reactome | Defective OPN1LW does not bind 11cRAL

Schema > FailedReaction > Entries

Defective OPN1LW does not bind 11cRAL Show undefined attributes

authored	[InstanceEdit:2466812] Jassal, Bijay, 2012-09-12
category	transition
compartment	[Compartment:70101] cytosol [Compartment:74000] photoreceptor outer segment membrane
created	[InstanceEdit:2466812] Jassal, Bijay, 2012-09-12
crossReference	[DatabaseIdentifier:12020954] Mondo:0001703
dbId	2466822
deleted	[Deleted:9919293] Deletion of instance: 2471660
disease	[Disease:9918439] color blindness
displayName	Defective OPN1LW does not bind 11cRAL
edited	[InstanceEdit:2466812] Jassal, Bijay, 2012-09-12 [InstanceEdit:9918451] Orlic-Milacic, Marija, 2024-08-15
entityFunctionalStatus	[EntityFunctionalStatus:2471684] loss_of_function of OPN1LW LOF variants [photoreceptor disc membrane]
eventOf	[Pathway:R-HSA-9918450] Defective visual phototransduction due to OPN1LW loss of function - Homo sapiens
input	[SimpleEntity:R-ALL-32737] 11cRAL [cytosol] [DefinedSet:R-HSA-9918457] OPN1LW LOF variants [photoreceptor disc membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2471677] Gene conversion between red and defective green opsin gene in blue cone monochromacy [LiteratureReference:2471710] Genetic heterogeneity among blue-cone monochromats [LiteratureReference:2471734] Molecular genetics of human blue cone monochromacy [LiteratureReference:2471709] Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies
maxDepth	1
modified	[InstanceEdit:9919314] Matthews, Lisa, 2024-08-21
name	Defective OPN1LW does not bind 11cRAL
normalReaction	[Reaction:R-HSA-2465924] OPN1LW binds 11cRAL
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3006584] Blaner, William S, 2013-01-31 [InstanceEdit:9919313] Matthews, Lisa, 2024-08-21
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2466822
summation	[Summation:2471719] Normal human colour vision is trichromatic, based on 3 types...
updateTrackers	[UpdateTracker:9919484] Update Tracker - [FailedReaction:2466822] Defective OPN1LW does not bind 11cRAL - v90:[add_removeInput, modifyText] [UpdateTracker:9779961] Update Tracker - [FailedReaction:2466822] Defective OPN1LW causes BCM - v64:[add_removeInput] [UpdateTracker:9777633] Update Tracker - [FailedReaction:2466822] Defective OPN1LW causes BCM - v70:[removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9919484] Update Tracker - [FailedReaction:2466822] Defective OPN1LW does not bind 11cRAL - v90:[add_removeInput, modifyText] [UpdateTracker:9779961] Update Tracker - [FailedReaction:2466822] Defective OPN1LW causes BCM - v64:[add_removeInput] [UpdateTracker:9777633] Update Tracker - [FailedReaction:2466822] Defective OPN1LW causes BCM - v70:[removeInput]
(replacementInstances)	[Deleted:9919293] Deletion of instance: 2471660
(hasEvent)	[Pathway:R-HSA-9918450] Defective visual phototransduction due to OPN1LW loss of function