Reactome | Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs

Schema > FailedReaction > Entries

Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs Show undefined attributes

authored	[InstanceEdit:2466812] Jassal, Bijay, 2012-09-12
catalystActivity	[CatalystActivity:9631771] O-palmitoyltransferase activity of LRAT S175R [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:2466812] Jassal, Bijay, 2012-09-12
crossReference	[DatabaseIdentifier:12020957] Mondo:0018998
dbId	2466710
disease	[Disease:2471664] Leber congenital amaurosis
displayName	Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs
edited	[InstanceEdit:2466812] Jassal, Bijay, 2012-09-12
entityFunctionalStatus	[EntityFunctionalStatus:2466776] loss_of_function of LRAT S175R [endoplasmic reticulum membrane]
eventOf	[Pathway:R-HSA-9918442] Defective visual phototransduction due to LRAT loss of function - Homo sapiens
input	[Complex:R-HSA-2864101] RBP1:atROL [cytosol] [SimpleEntity:R-ALL-9982900] RCOO- [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2466740] Leber congenital amaurosis: clinical correlations with genotypes, gene therapy trials update, and future directions [LiteratureReference:2466713] Mutations in the gene encoding lecithin retinol acyltransferase are associated with early-onset severe retinal dystrophy [LiteratureReference:2466707] Screening genes of the retinoid metabolism: novel LRAT mutation in leber congenital amaurosis [LiteratureReference:2466843] Identification of novel mutations in patients with Leber congenital amaurosis and juvenile RP by genome-wide homozygosity mapping with SNP microarrays
maxDepth	1
modified	[InstanceEdit:9984898] Weiser, Joel, 2026-03-12
name	Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs
normalReaction	[Reaction:R-HSA-2453855] LRAT esterifies RBP1:atROL and FACYLs to atREs
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2013-03-12
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3006584] Blaner, William S, 2013-01-31 [InstanceEdit:9982913] D'Eustachio, Peter, 2026-02-20
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2466710
summation	[Summation:2466798] Normally functioning lecithin retinol acyltransferase (LRAT)...
updateTrackers	[UpdateTracker:9779932] Update Tracker - [FailedReaction:2466710] Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs - v64:[add_removeInput] [UpdateTracker:9778135] Update Tracker - [FailedReaction:2466710] Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs - v68:[addCatalystActivity] [UpdateTracker:9984593] Update Tracker - [FailedReaction:2466710] Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs - v96:[add_removeInput]

Referrals

(updatedInstance)

[UpdateTracker:9779932] Update Tracker - [FailedReaction:2466710] Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs - v64:[add_removeInput]
[UpdateTracker:9778135] Update Tracker - [FailedReaction:2466710] Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs - v68:[addCatalystActivity]
[UpdateTracker:9984593] Update Tracker - [FailedReaction:2466710] Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs - v96:[add_removeInput]

(hasEvent)

[Pathway:R-HSA-9918442] Defective visual phototransduction due to LRAT loss of function