Reactome | Defective OPN1MW does not bind 11cRAL

Schema > FailedReaction > Entries

Defective OPN1MW does not bind 11cRAL Show undefined attributes

authored	[InstanceEdit:2466812] Jassal, Bijay, 2012-09-12
category	transition
compartment	[Compartment:70101] cytosol [Compartment:74000] photoreceptor outer segment membrane
created	[InstanceEdit:2466812] Jassal, Bijay, 2012-09-12
crossReference	[DatabaseIdentifier:12020952] Mondo:0005283
dbId	2466706
deleted	[Deleted:9919294] Deletion of instance: 2471641
disease	[Disease:2477157] retinal disease
displayName	Defective OPN1MW does not bind 11cRAL
edited	[InstanceEdit:2466812] Jassal, Bijay, 2012-09-12 [InstanceEdit:9918451] Orlic-Milacic, Marija, 2024-08-15
entityFunctionalStatus	[EntityFunctionalStatus:2470744] loss_of_function of OPN1MW LOF variants [photoreceptor disc membrane]
eventOf	[Pathway:R-HSA-9918436] Defective visual phototransduction due to OPN1MW loss of function - Homo sapiens
input	[SimpleEntity:R-ALL-32737] 11cRAL [cytosol] [DefinedSet:R-HSA-9918435] OPN1MW LOF variants [photoreceptor disc membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2471759] The molecular basis of dichromatic color vision in males with multiple red and green visual pigment genes [LiteratureReference:420860] Defective colour vision associated with a missense mutation in the human green visual pigment gene [LiteratureReference:2471709] Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies [LiteratureReference:2471734] Molecular genetics of human blue cone monochromacy [LiteratureReference:2471710] Genetic heterogeneity among blue-cone monochromats [LiteratureReference:2471677] Gene conversion between red and defective green opsin gene in blue cone monochromacy [LiteratureReference:2471633] X-linked cone dystrophy caused by mutation of the red and green cone opsins
maxDepth	1
modified	[InstanceEdit:9919313] Matthews, Lisa, 2024-08-21
name	Defective OPN1MW does not bind 11cRAL
normalReaction	[Reaction:R-HSA-9656893] OPN1MW binds 11cRAL
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3006584] Blaner, William S, 2013-01-31 [InstanceEdit:9919312] Matthews, Lisa, 2024-08-21
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2466706
summation	[Summation:2470748] Normal human colour vision is trichromatic, based on 3 types...
updateTrackers	[UpdateTracker:9919387] Update Tracker - [FailedReaction:2466706] Defective OPN1MW does not bind 11cRAL - v90:[add_removeInput, modifyText, removeLiteratureReference] [UpdateTracker:9777656] Update Tracker - [FailedReaction:2466706] Defective OPN1MW causes DCB and BCM - v70:[removeInput] [UpdateTracker:9779983] Update Tracker - [FailedReaction:2466706] Defective OPN1MW causes DCB and BCM - v64:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9919387] Update Tracker - [FailedReaction:2466706] Defective OPN1MW does not bind 11cRAL - v90:[add_removeInput, modifyText, removeLiteratureReference] [UpdateTracker:9777656] Update Tracker - [FailedReaction:2466706] Defective OPN1MW causes DCB and BCM - v70:[removeInput] [UpdateTracker:9779983] Update Tracker - [FailedReaction:2466706] Defective OPN1MW causes DCB and BCM - v64:[add_removeInput]
(replacementInstances)	[Deleted:9919294] Deletion of instance: 2471641
(hasEvent)	[Pathway:R-HSA-9918436] Defective visual phototransduction due to OPN1MW loss of function