Reactome | PIK3R1 N564D [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2399428] Orlic-Milacic, M, 2012-07-09
crossReference	[DatabaseIdentifier:12020752] Mondo:0005575 [DatabaseIdentifier:2399422] COSMIC:COSV57124003
dbId	2399427
disease	[Disease:1500689] cancer [Disease:2317358] endometrial cancer [Disease:1248674] large intestine cancer [Disease:1247632] glioblastoma
displayName	PIK3R1 N564D [plasma membrane]
endCoordinate	724
hasModifiedResidue	[ReplacedResidue:2399424] L-asparagine 564 replaced with L-aspartic acid
inDisease	true
literatureReference	[LiteratureReference:2399688] Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation
maxDepth	1
memberOf	[CandidateSet:R-HSA-2399665] PIK3R1 iSH2 domain mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:5624358] Jupe, Steve, 2014-09-26
name	PIK3R1 N564D PIK3R1 Asn564Asp
referenceEntity	[ReferenceGeneProduct:uniprot:P27986] UniProt:P27986 PIK3R1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2399427
startCoordinate	1
summation	[Summation:2399710] The substitution of asparagine residue with aspartic acid at...
updateTrackers	[UpdateTracker:9887530] Update Tracker - [EntityWithAccessionedSequence:2399427] PIK3R1 N564D [plasma membrane] - v46:[modifyName]

(updatedInstance)	[UpdateTracker:9887530] Update Tracker - [EntityWithAccessionedSequence:2399427] PIK3R1 N564D [plasma membrane] - v46:[modifyName]
(hasMember)	[CandidateSet:R-HSA-2399665] PIK3R1 iSH2 domain mutants [plasma membrane]

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