Reactome | Latent TGF-beta-1 binds integrins

Schema > Reaction > Entries

Latent TGF-beta-1 binds integrins Show undefined attributes

authored	[InstanceEdit:2214334] Jupe, S, 2012-04-30
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2395344] Jupe, S, 2012-06-29
dbId	2395320
displayName	Latent TGF-beta-1 binds integrins
edited	[InstanceEdit:2580335] Jupe, S, 2012-11-12
eventOf	[Pathway:R-HSA-2129379] Molecules associated with elastic fibres - Homo sapiens
input	[DefinedSet:R-HSA-2396176] LAP1 binding-integrins [plasma membrane] [Complex:R-HSA-9737594] LTBP1:TGFB1:LAP1 [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2395368] Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1 [LiteratureReference:2395371] The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis [LiteratureReference:2395234] The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3 [LiteratureReference:2395246] The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1 [LiteratureReference:2395309] Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Latent TGF-beta-1 binds integrins
orthologousEvent	[Reaction:R-DME-2395320] Latent TGF-beta-1 binds integrins - Drosophila melanogaster [Reaction:R-XTR-2395320] Latent TGF-beta-1 binds integrins - Xenopus tropicalis [Reaction:R-SSC-2395320] Latent TGF-beta-1 binds integrins - Sus scrofa [Reaction:R-BTA-2395320] Latent TGF-beta-1 binds integrins - Bos taurus [Reaction:R-CFA-2395320] Latent TGF-beta-1 binds integrins - Canis familiaris [Reaction:R-RNO-2395320] Latent TGF-beta-1 binds integrins - Rattus norvegicus [Reaction:R-MMU-2395320] Latent TGF-beta-1 binds integrins - Mus musculus
output	[Complex:R-HSA-2396201] LTBP1:TGFB1:LAP1:LAP1-binding integrins [plasma membrane]
precedingEvent	[Reaction:R-HSA-2395328] LTBP1, LTBP3 bind TGF-Beta - Homo sapiens
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2550420] Muiznieks, Lisa, 2012-11-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2395320
summation	[Summation:2395334] The LAPs of TGF beta-1 and TGF beta-3 contain RGD sequences ...
updateTrackers	[UpdateTracker:9775577] Update Tracker - [Reaction:2395320] Latent TGF-beta-1 binds integrins - v78:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9775577] Update Tracker - [Reaction:2395320] Latent TGF-beta-1 binds integrins - v78:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-2129379] Molecules associated with elastic fibres [Pathway:R-HSA-2173789] TGF-beta receptor signaling activates SMADs