Latent TGF-beta-1 binds integrins

Stable Identifier
R-HSA-2395320
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The LAPs of TGF beta-1 and TGF beta-3 contain RGD sequences near the carboxyl termini that are bound by RGD binding integrins. The TGF beta-1 form of LAP (LAP1) binds the integrins alphaVBeta1 (Munger et al. 1998), alphaVBeta3 (Ludbrook et al. 2003), alphaVBeta5 (Munger et al. 1998), alphaVBeta6 (Munger et al. 1999, Araya et al. 2006), alphaVBeta8 (Mu et al. 2002, Araya et al. 2006) and alpha8Beta1 (Lu et al. 2002). Binding to integrins alphaVBeta6 and alphaVBeta8 leads to TGF beta activation.

Literature References
PubMed ID Title Journal Year
9725916 Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1

Munger, JS, Harpel, JG, Giancotti, FG, Rifkin, DB

Mol. Biol. Cell 1998
10025398 The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

Munger, JS, Huang, X, Kawakatsu, H, Griffiths, MJ, Dalton, SL, Wu, J, Pittet, JF, Kaminski, N, Garat, C, Matthay, MA, Rifkin, DB, Sheppard, D

Cell 1999
11970960 The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1

Mu, D, Cambier, S, Fjellbirkeland, L, Baron, JL, Munger, JS, Kawakatsu, H, Sheppard, D, Broaddus, VC, Nishimura, SL

J. Cell Biol. 2002
12415008 Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1

Lu, M, Munger, JS, Steadele, M, Busald, C, Tellier, M, Schnapp, LM

J. Cell. Sci. 2002
12358597 The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3

Ludbrook, SB, Barry, ST, Delves, CJ, Horgan, CM

Biochem. J. 2003
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