Reactome | Latent TGF-beta-1 binds integrins

Latent TGF-beta-1 binds integrins

Stable Identifier

R-HSA-2395320

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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The LAPs of TGF beta-1 and TGF beta-3 contain RGD sequences near the carboxyl termini that are bound by RGD binding integrins. The TGF beta-1 form of LAP (LAP1) binds the integrins alphaVBeta1 (Munger et al. 1998), alphaVBeta3 (Ludbrook et al. 2003), alphaVBeta5 (Munger et al. 1998), alphaVBeta6 (Munger et al. 1999, Araya et al. 2006), alphaVBeta8 (Mu et al. 2002, Araya et al. 2006) and alpha8Beta1 (Lu et al. 2002). Binding to integrins alphaVBeta6 and alphaVBeta8 leads to TGF beta activation.

Literature References

PubMed ID	Title	Journal	Year
10025398	The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis Garat, C, Sheppard, D, Rifkin, DB, Matthay, MA, Griffiths, MJ, Kawakatsu, H, Huang, X, Kaminski, N, Munger, JS, Wu, J, Pittet, JF, Dalton, SL	Cell	1999
9725916	Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1 Harpel, JG, Rifkin, DB, Giancotti, FG, Munger, JS	Mol. Biol. Cell	1998
11970960	The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1 Nishimura, SL, Broaddus, VC, Kawakatsu, H, Baron, JL, Fjellbirkeland, L, Sheppard, D, Cambier, S, Mu, D, Munger, JS	J. Cell Biol.	2002
12415008	Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1 Lu, M, Steadele, M, Busald, C, Schnapp, LM, Munger, JS, Tellier, M	J. Cell. Sci.	2002
12358597	The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3 Horgan, CM, Delves, CJ, Ludbrook, SB, Barry, ST	Biochem. J.	2003