Reactome | PIK3CA Q546E [cytosol]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-HSA-2399587] PIK3CA helical domain mutants [cytosol] - Homo sapiens
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2362387] Orlic-Milacic, M, 2012-06-27
crossReference	[DatabaseIdentifier:12020752] Mondo:0005575 [DatabaseIdentifier:2362386] COSMIC:COSV55882350
dbId	2362383
disease	[Disease:1248674] large intestine cancer [Disease:1500689] cancer [Disease:1500576] breast cancer [Disease:2317358] endometrial cancer [Disease:1614672] cervical cancer
displayName	PIK3CA Q546E [cytosol]
endCoordinate	1068
hasModifiedResidue	[ReplacedResidue:2362384] L-glutamine 546 replaced with L-glutamic acid
inDisease	true
literatureReference	[LiteratureReference:2399592] Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
maxDepth	1
modified	[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
name	PIK3CA Q546E PIK3CA Gln546Glu
referenceEntity	[ReferenceGeneProduct:uniprot:P42336] UniProt:P42336 PIK3CA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2362383
startCoordinate	1
summation	[Summation:2399626] Based on structural and functional studies of PIK3CA Q546K m...
updateTrackers	[UpdateTracker:9887979] Update Tracker - [EntityWithAccessionedSequence:2362383] PIK3CA Q546E [cytosol] - v46:[modifyName]

(updatedInstance)	[UpdateTracker:9887979] Update Tracker - [EntityWithAccessionedSequence:2362383] PIK3CA Q546E [cytosol] - v46:[modifyName]
(hasCandidate)	[CandidateSet:R-HSA-2399587] PIK3CA helical domain mutants [cytosol]

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