Reactome | PIK3CA E545Q [cytosol]

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PIK3CA E545Q [cytosol] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-2399587] PIK3CA helical domain mutants [cytosol] - Homo sapiens
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2362364] Orlic-Milacic, M, 2012-06-27
crossReference	[DatabaseIdentifier:12020752] Mondo:0005575 [DatabaseIdentifier:2362366] COSMIC:COSV55878227
dbId	2362362
disease	[Disease:1248674] large intestine cancer [Disease:1500689] cancer [Disease:1500576] breast cancer [Disease:1500575] ovarian cancer [Disease:1493885] bladder carcinoma [Disease:2327998] esophageal carcinoma [Disease:1655470] thyroid cancer [Disease:1248679] head and neck squamous cell carcinoma
displayName	PIK3CA E545Q [cytosol]
endCoordinate	1068
hasModifiedResidue	[ReplacedResidue:2362361] L-glutamic acid 545 replaced with L-glutamine
inDisease	true
literatureReference	[LiteratureReference:2399592] Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit [LiteratureReference:2399562] The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations [LiteratureReference:2399575] The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells
maxDepth	1
modified	[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
name	PIK3CA E545Q PIK3CA Glu545Gln
referenceEntity	[ReferenceGeneProduct:uniprot:P42336] UniProt:P42336 PIK3CA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2362362
startCoordinate	1
summation	[Summation:2399595] Based on structural and functional studies of the PIK3CA E54...
updateTrackers	[UpdateTracker:9888218] Update Tracker - [EntityWithAccessionedSequence:2362362] PIK3CA E545Q [cytosol] - v46:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9888218] Update Tracker - [EntityWithAccessionedSequence:2362362] PIK3CA E545Q [cytosol] - v46:[modifyName]
(hasCandidate)	[CandidateSet:R-HSA-2399587] PIK3CA helical domain mutants [cytosol]

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