Reactome | PIK3CA E545A [cytosol]

Schema > EntityWithAccessionedSequence > Entries

PIK3CA E545A [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2362359] Orlic-Milacic, M, 2012-06-27
crossReference	[DatabaseIdentifier:12021362] Mondo:0010434 [DatabaseIdentifier:2362358] COSMIC:COSV55873209
dbId	2362355
disease	[Disease:1248674] large intestine cancer [Disease:1500689] cancer [Disease:2317358] endometrial cancer [Disease:1500576] breast cancer [Disease:1247632] glioblastoma [Disease:1500575] ovarian cancer [Disease:1655470] thyroid cancer [Disease:2327998] esophageal carcinoma [Disease:1655499] prostate cancer [Disease:2362360] synovial sarcoma [Disease:1500699] lung cancer [Disease:2362357] hepatoblastoma [Disease:1500687] stomach cancer
displayName	PIK3CA E545A [cytosol]
endCoordinate	1068
hasModifiedResidue	[ReplacedResidue:2362356] L-glutamic acid 545 replaced with L-alanine
inDisease	true
literatureReference	[LiteratureReference:2399562] The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations [LiteratureReference:2399592] Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit [LiteratureReference:2399575] The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells [LiteratureReference:2399617] Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells
maxDepth	1
memberOf	[CandidateSet:R-HSA-2399587] PIK3CA helical domain mutants [cytosol] - Homo sapiens
modified	[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
name	PIK3CA E545A PIK3CA Glu545Ala
referenceEntity	[ReferenceGeneProduct:uniprot:P42336] UniProt:P42336 PIK3CA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2362355
startCoordinate	1
summation	[Summation:2399599] Similar to PIK3CA E545K mutant (Miled et al. 2007, Huang et ...
updateTrackers	[UpdateTracker:9887729] Update Tracker - [EntityWithAccessionedSequence:2362355] PIK3CA E545A [cytosol] - v46:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9887729] Update Tracker - [EntityWithAccessionedSequence:2362355] PIK3CA E545A [cytosol] - v46:[modifyName]
(hasMember)	[CandidateSet:R-HSA-2399587] PIK3CA helical domain mutants [cytosol]