Reactome | PIK3CA E542V [cytosol]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-HSA-2399587] PIK3CA helical domain mutants [cytosol] - Homo sapiens
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2328075] Orlic-Milacic, M, 2012-06-22
crossReference	[DatabaseIdentifier:12020752] Mondo:0005575 [DatabaseIdentifier:2328076] COSMIC:COSV55881194
dbId	2328074
disease	[Disease:1248674] large intestine cancer [Disease:1500689] cancer [Disease:1500576] breast cancer [Disease:2317358] endometrial cancer [Disease:1500575] ovarian cancer
displayName	PIK3CA E542V [cytosol]
endCoordinate	1068
hasModifiedResidue	[ReplacedResidue:2328077] L-glutamic acid 542 replaced with L-valine
inDisease	true
literatureReference	[LiteratureReference:2399592] Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
maxDepth	1
modified	[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
name	PIK3CA E542V PIK3CA Glu542Val
referenceEntity	[ReferenceGeneProduct:uniprot:P42336] UniProt:P42336 PIK3CA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2328074
startCoordinate	1
summation	[Summation:2399616] Based on structural and functional studies of PIK3CA E542K m...
updateTrackers	[UpdateTracker:9888522] Update Tracker - [EntityWithAccessionedSequence:2328074] PIK3CA E542V [cytosol] - v46:[modifyName]

(updatedInstance)	[UpdateTracker:9888522] Update Tracker - [EntityWithAccessionedSequence:2328074] PIK3CA E542V [cytosol] - v46:[modifyName]
(hasCandidate)	[CandidateSet:R-HSA-2399587] PIK3CA helical domain mutants [cytosol]

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