Reactome | PTEN H93D [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2318563] Orlic-Milacic, M, 2012-06-13
crossReference	[DatabaseIdentifier:12020781] Mondo:0011962 [DatabaseIdentifier:2318556] COSMIC:COSV64299563
dbId	2318550
disease	[Disease:1500689] cancer [Disease:2317358] endometrial cancer
displayName	PTEN H93D [cytosol]
endCoordinate	403
hasModifiedResidue	[ReplacedResidue:2318554] L-histidine 93 replaced with L-aspartic acid
inDisease	true
literatureReference	[LiteratureReference:2318559] A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes
maxDepth	1
memberOf	[CandidateSet:R-HSA-2317372] PTEN Phosphatase Domain Missense Mutants [cytosol] - Homo sapiens
modified	[InstanceEdit:9967512] D'Eustachio, Peter, 2025-09-30
name	PTEN H93D PTEN His93Asp
referenceEntity	[ReferenceGeneProduct:uniprot:P60484] UniProt:P60484 PTEN
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2318550
startCoordinate	2
summation	[Summation:2318552] PTEN missense mutation that results in the substitution of h...
updateTrackers	[UpdateTracker:9972490] Update Tracker - [EntityWithAccessionedSequence:2318550] PTEN H93D [cytosol] - v95:[modifyStartCoordinate] [UpdateTracker:9887986] Update Tracker - [EntityWithAccessionedSequence:2318550] PTEN H93D [cytosol] - v46:[modifyName]

(updatedInstance)	[UpdateTracker:9972490] Update Tracker - [EntityWithAccessionedSequence:2318550] PTEN H93D [cytosol] - v95:[modifyStartCoordinate] [UpdateTracker:9887986] Update Tracker - [EntityWithAccessionedSequence:2318550] PTEN H93D [cytosol] - v46:[modifyName]
(hasMember)	[CandidateSet:R-HSA-2317372] PTEN Phosphatase Domain Missense Mutants [cytosol]

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