Reactome | PTEN S170G [cytosol]

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PTEN S170G [cytosol] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-2317372] PTEN Phosphatase Domain Missense Mutants [cytosol] - Homo sapiens
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2318464] Orlic-Milacic, M, 2012-06-13
crossReference	[DatabaseIdentifier:12020790] Mondo:0018177 [DatabaseIdentifier:2318463] COSMIC:COSV64303094
dbId	2318465
disease	[Disease:1500689] cancer [Disease:1247632] glioblastoma
displayName	PTEN S170G [cytosol]
endCoordinate	403
hasModifiedResidue	[ReplacedResidue:2318462] L-serine 170 replaced with glycine
inDisease	true
literatureReference	[LiteratureReference:1889775] Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay [LiteratureReference:2317505] Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association
maxDepth	1
modified	[InstanceEdit:9967512] D'Eustachio, Peter, 2025-09-30
name	PTEN S170G PTEN Ser170Gly
referenceEntity	[ReferenceGeneProduct:uniprot:P60484] UniProt:P60484 PTEN
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2318465
startCoordinate	2
summation	[Summation:2318461] PTEN missense mutation that results in the substitution of s...
updateTrackers	[UpdateTracker:9972705] Update Tracker - [EntityWithAccessionedSequence:2318465] PTEN S170G [cytosol] - v95:[modifyStartCoordinate] [UpdateTracker:9888599] Update Tracker - [EntityWithAccessionedSequence:2318465] PTEN S170G [cytosol] - v46:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9972705] Update Tracker - [EntityWithAccessionedSequence:2318465] PTEN S170G [cytosol] - v95:[modifyStartCoordinate] [UpdateTracker:9888599] Update Tracker - [EntityWithAccessionedSequence:2318465] PTEN S170G [cytosol] - v46:[modifyName]
(hasCandidate)	[CandidateSet:R-HSA-2317372] PTEN Phosphatase Domain Missense Mutants [cytosol]

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