Reactome | PTEN S170R [cytosol]

Schema > EntityWithAccessionedSequence > Entries

PTEN S170R [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2318439] Orlic-Milacic, M, 2012-06-13
crossReference	[DatabaseIdentifier:12021347] Mondo:0007924
dbId	2318437
disease	[Disease:2318444] Bannayan-Riley-Ruvalcaba syndrome [Disease:1500689] cancer
displayName	PTEN S170R [cytosol]
endCoordinate	403
hasModifiedResidue	[ReplacedResidue:2318442] L-serine 170 replaced with L-arginine
inDisease	true
literatureReference	[LiteratureReference:1889775] Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay [LiteratureReference:2317505] Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association [LiteratureReference:2318432] Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation
maxDepth	1
memberOf	[CandidateSet:R-HSA-2317372] PTEN Phosphatase Domain Missense Mutants [cytosol] - Homo sapiens
modified	[InstanceEdit:9967512] D'Eustachio, Peter, 2025-09-30
name	PTEN S170R PTEN Ser170Arg
referenceEntity	[ReferenceGeneProduct:uniprot:P60484] UniProt:P60484 PTEN
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2318437
startCoordinate	2
summation	[Summation:2318415] PTEN missense mutation that results in the substitution of s...
updateTrackers	[UpdateTracker:9972613] Update Tracker - [EntityWithAccessionedSequence:2318437] PTEN S170R [cytosol] - v95:[modifyStartCoordinate] [UpdateTracker:9887789] Update Tracker - [EntityWithAccessionedSequence:2318437] PTEN S170R [cytosol] - v46:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9972613] Update Tracker - [EntityWithAccessionedSequence:2318437] PTEN S170R [cytosol] - v95:[modifyStartCoordinate] [UpdateTracker:9887789] Update Tracker - [EntityWithAccessionedSequence:2318437] PTEN S170R [cytosol] - v46:[modifyName]
(hasMember)	[CandidateSet:R-HSA-2317372] PTEN Phosphatase Domain Missense Mutants [cytosol]