Reactome | PTEN R173P [cytosol]

Schema > EntityWithAccessionedSequence > Entries

PTEN R173P [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2317483] Orlic-Milacic, M, 2012-06-11
crossReference	[DatabaseIdentifier:12021348] Mondo:0010108 [DatabaseIdentifier:2317486] COSMIC:COSV64302184
dbId	2317480
disease	[Disease:2317481] testicular germ cell cancer [Disease:1500689] cancer
displayName	PTEN R173P [cytosol]
endCoordinate	403
hasModifiedResidue	[ReplacedResidue:2317477] L-arginine 173 replaced with L-proline
inDisease	true
literatureReference	[LiteratureReference:1889775] Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay [LiteratureReference:2317505] Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association
maxDepth	1
memberOf	[CandidateSet:R-HSA-2317372] PTEN Phosphatase Domain Missense Mutants [cytosol] - Homo sapiens
modified	[InstanceEdit:9967512] D'Eustachio, Peter, 2025-09-30
name	PTEN R173P PTEN Arg173Pro
referenceEntity	[ReferenceGeneProduct:uniprot:P60484] UniProt:P60484 PTEN
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2317480
startCoordinate	2
summation	[Summation:2317485] PTEN missense mutation that results in the substitution of a...
updateTrackers	[UpdateTracker:9888426] Update Tracker - [EntityWithAccessionedSequence:2317480] PTEN R173P [cytosol] - v46:[modifyName] [UpdateTracker:9972851] Update Tracker - [EntityWithAccessionedSequence:2317480] PTEN R173P [cytosol] - v95:[modifyStartCoordinate]

Referrals

(updatedInstance)	[UpdateTracker:9888426] Update Tracker - [EntityWithAccessionedSequence:2317480] PTEN R173P [cytosol] - v46:[modifyName] [UpdateTracker:9972851] Update Tracker - [EntityWithAccessionedSequence:2317480] PTEN R173P [cytosol] - v95:[modifyStartCoordinate]
(hasMember)	[CandidateSet:R-HSA-2317372] PTEN Phosphatase Domain Missense Mutants [cytosol]

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