Reactome | PTEN R130P [cytosol]

Schema > EntityWithAccessionedSequence > Entries

PTEN R130P [cytosol] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-2317372] PTEN Phosphatase Domain Missense Mutants [cytosol] - Homo sapiens
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2317435] Orlic-Milacic, M, 2012-06-11
crossReference	[DatabaseIdentifier:12020790] Mondo:0018177 [DatabaseIdentifier:2317434] COSMIC:COSV64288604
dbId	2317432
disease	[Disease:2317358] endometrial cancer [Disease:1500576] breast cancer [Disease:1247632] glioblastoma [Disease:1500689] cancer
displayName	PTEN R130P [cytosol]
endCoordinate	403
hasModifiedResidue	[ReplacedResidue:2317436] L-arginine 130 replaced with L-proline
inDisease	true
literatureReference	[LiteratureReference:1889775] Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay [LiteratureReference:2317493] Crystal structure of human protein tyrosine phosphatase 1B [LiteratureReference:2317505] Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association
maxDepth	1
modified	[InstanceEdit:9967512] D'Eustachio, Peter, 2025-09-30
name	PTEN R130P PTEN Arg130Pro
referenceEntity	[ReferenceGeneProduct:uniprot:P60484] UniProt:P60484 PTEN
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2317432
startCoordinate	2
summation	[Summation:2317433] PTEN missense mutation that results in the substitution of a...
updateTrackers	[UpdateTracker:9887989] Update Tracker - [EntityWithAccessionedSequence:2317432] PTEN R130P [cytosol] - v46:[modifyName] [UpdateTracker:9972665] Update Tracker - [EntityWithAccessionedSequence:2317432] PTEN R130P [cytosol] - v95:[modifyStartCoordinate]

Referrals

(updatedInstance)	[UpdateTracker:9887989] Update Tracker - [EntityWithAccessionedSequence:2317432] PTEN R130P [cytosol] - v46:[modifyName] [UpdateTracker:9972665] Update Tracker - [EntityWithAccessionedSequence:2317432] PTEN R130P [cytosol] - v95:[modifyStartCoordinate]
(hasCandidate)	[CandidateSet:R-HSA-2317372] PTEN Phosphatase Domain Missense Mutants [cytosol]