Reactome | Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex

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Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex Show undefined attributes

authored	[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
category	dissociation
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2262776] Shamovsky, V, 2012-05-21
dbId	2262775
displayName	Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
edited	[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
eventOf	[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Homo sapiens
input	[Complex:R-HSA-2262774] TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:165896] Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling [LiteratureReference:450126] IRAK1: a critical signaling mediator of innate immunity
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
output	[Complex:R-HSA-937048] p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane] 4 × [Complex:R-HSA-936961] TRAF6:p-IRAK2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-2262777] TRAF6 binds to p-IRAK2 - Homo sapiens
relatedSpecies	[Species:180800] Neisseria meningitidis serogroup B [Species:181384] Chlamydia trachomatis
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16
revised	[InstanceEdit:937065] Shamovsky, V, 2010-08-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2262775
summation	[Summation:940394] Hyperphosphorylated IRAK1 and TRAF6 are thought to dissociat...
updateTrackers	[UpdateTracker:9788263] Update Tracker - [Reaction:2262775] Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex - v43:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788263] Update Tracker - [Reaction:2262775] Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex - v43:[modifyText]
(hasEvent)	[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane

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